TOLLIP

Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.[5][6][7]

TOLLIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTOLLIP, IL-1RAcPIP, toll interacting protein
External IDsOMIM: 606277 MGI: 1891808 HomoloGene: 10375 GeneCards: TOLLIP
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.5Start1,274,371 bp[1]
End1,309,654 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54472

54473

Ensembl

ENSG00000078902

ENSMUSG00000025139

UniProt

Q9H0E2
Q6FIE9

Q9QZ06

RefSeq (mRNA)

NM_019009
NM_001318512
NM_001318514
NM_001318515
NM_001318516

NM_023764
NM_001347562

RefSeq (protein)

NP_001334491
NP_076253

Location (UCSC)Chr 11: 1.27 – 1.31 MbChr 7: 141.87 – 141.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

It is an inhibitory adaptor protein within Toll-like receptors (TLR).[8] The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.

Clinical significance

Polymorphisms in TLR genes have been implicated in various diseases like atopic dermatitis.[9] Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.[10][11]

Interactions

TOLLIP has been shown to interact with TOM1,[12] TLR 2,[13] TLR 4[13] and IL1RAP.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000078902 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025139 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TOLLIP toll interacting protein".
  6. Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Letters. 419 (1): 41–4. doi:10.1016/S0014-5793(97)01426-9. PMID 9426216. S2CID 39772937.
  7. Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
  8. Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling". Journal of Immunology. 167 (2): 987–94. doi:10.4049/jimmunol.167.2.987. PMID 11441107.
  9. Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S (March 2007). "Association of toll-interacting protein gene polymorphisms with atopic dermatitis". BMC Dermatology. 7: 3. doi:10.1186/1471-5945-7-3. PMC 1832210. PMID 17362526.
  10. Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, et al. (August 2012). "Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis". Journal of Immunology. 189 (4): 1737–46. doi:10.4049/jimmunol.1103541. PMC 3428135. PMID 22778396.
  11. Gilgenkrantz S, Droulle P, Schweitzer M, Foliguet B, Gérard H, Plénat F (June 1985). "[Prenatal diagnosis of triploidy. I. Echographic, clinical and anatomic studies]". Journal de Génétique Humaine. 33 (2): 143–52. doi:10.1016/S2213-2600(13)70045-6. PMC 3894577. PMID 24429156.
  12. Yamakami M, Yoshimori T, Yokosawa H (December 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". The Journal of Biological Chemistry. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. PMID 14563850.
  13. Zhang G, Ghosh S (March 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip". The Journal of Biological Chemistry. 277 (9): 7059–65. doi:10.1074/jbc.M109537200. PMID 11751856.

Further reading

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