TRNA dimethylallyltransferase
TRNA dimethylallyltransferase (EC 2.5.1.75, tRNA prenyltransferase, MiaA, transfer ribonucleate isopentenyltransferase, Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl transferase, Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid Delta2-isopentenyltransferase) is an enzyme with systematic name dimethylallyl-diphosphate: tRNA dimethylallyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- dimethylallyl diphosphate + tRNA diphosphate + tRNA containing 6-dimethylallyladenosine
| TRNA dimethylallyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.75 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Formerly known as tRNA isopentenyltransferase (EC 2.5.1.8), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.
References
- Leung HC, Chen Y, Winkler ME (May 1997). "Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12". The Journal of Biological Chemistry. 272 (20): 13073–83. doi:10.1074/jbc.272.20.13073. PMID 9148919.
- Soderberg T, Poulter CD (May 2000). "Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop". Biochemistry. 39 (21): 6546–53. doi:10.1021/bi992775u. PMID 10828971.
- Moore JA, Mathis JR, Poulter CD (June 2000). "Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: pre-steady-state kinetic studies". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1479 (1–2): 166–74. doi:10.1016/S0167-4838(00)00031-5. PMID 11004538.
External links
- TRNA+dimethylallyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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