Dimethylallyltranstransferase

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Dimethylallyltranstransferase
Identifiers
EC number	2.5.1.1
CAS number	9032-79-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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FDPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YQ7, 1YV5, 1ZW5, 2F7M, 2F89, 2F8C, 2F8Z, 2F92, 2F94, 2F9K, 2OPM, 2OPN, 2QIS, 2RAH, 2VF6, 3B7L, 3CP6, 3N1V, 3N1W, 3N3L, 3N45, 3N46, 3N49, 3N5H, 3N5J, 3N6K, 3RYE, 3S4J, 4DEM, 4GA3, 4H5C, 4H5D, 4H5E, 4JVJ, 4KFA, 4KPD, 4KPJ, 4KQ5, 4KQS, 4KQU, 4L2X, 4LFV, 4LPG, 4LPH, 4N1Z, 4N9U, 4NFI, 4NFJ, 4NFK, 4NG6, 4NKE, 4NKF, 4NUA, 4OGU, 4P0V, 4P0W, 4P0X, 4PVX, 4PVY, 4Q23, 4QPF, 4QXS, 4RXA, 4XQR, 5CG5, 5DIQ, 5CG6, 5DJR, 5DJP, 4XQS, 5DJV, 5DGN, 4XQT, 5DGM, 5DGS
Identifiers
Aliases	FDPS, FPPS, FPS, POROK9, farnesyl diphosphate synthase
External IDs	OMIM: 134629 MGI: 104888 HomoloGene: 1519 GeneCards: FDPS
EC number	2.5.1.1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	155,320,666 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	89,101,959 bp[2]
Gene ontology
Molecular function	• transferase activity; • metal ion binding; • geranyltranstransferase activity; • dimethylallyltranstransferase activity; • RNA binding;
Cellular component	• nucleoplasm; • cytoplasm; • cytosol; • mitochondrion;
Biological process	• cholesterol biosynthetic process; • steroid metabolic process; • GO:0022415 viral process; • cholesterol metabolic process; • geranyl diphosphate biosynthetic process; • sterol biosynthetic process; • isoprenoid biosynthetic process; • lipid metabolism; • steroid biosynthetic process; • farnesyl diphosphate biosynthetic process; • regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2224
	110196
	ENSG00000160752
	ENSMUSG00000059743
	P14324
	Q920E5
	NM_001135821; NM_001135822; NM_001242824; NM_001242825; NM_002004
	NM_001253751; NM_134469
NP_001129293; NP_001129294; NP_001229753; NP_001229754; NP_001995;
	NP_001365353; NP_001365354
	NP_001240680; NP_608219
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).[5][6]

Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)

Identifiers

Symbol

FDPS

Other data

Chr. 1 q22

Search for
Structures	Swiss-model
Domains	InterPro

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

References

GRCh38: Ensembl release 89: ENSG00000160752 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059743 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15: 91–100. doi:10.1016/s0031-9422(00)89061-5.
Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID 736921.

External links

Dimethylallyltranstransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P14324 (Human Farnesyl pyrophosphate synthaseC) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160752 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059743 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15: 91–100. doi:10.1016/s0031-9422(00)89061-5.

[6] Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID 736921.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Dimethylallyltranstransferase

See also

References

External links