Tetrahydroxynaphthalene reductase
In enzymology, a tetrahydroxynaphthalene reductase (EC 1.1.1.252) is an enzyme that catalyzes the chemical reaction
- scytalone + NADP+ 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
| tetrahydroxynaphthalene reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.252 | ||||||||
| CAS number | 153702-05-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are scytalone and NADP+, whereas its 3 products are 1,3,6,8-tetrahydroxynaphthalene, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DOH, 1G0N, and 1G0O.
References
- Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)90004-7.
- Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994). "Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing". Eur. J. Biochem. 219 (3): 985–92. doi:10.1111/j.1432-1033.1994.tb18581.x. PMID 8112349.
- Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB (1997). "Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism". Biochemistry. 36 (7): 1852–60. doi:10.1021/bi962355u. PMID 9048570.
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