UDP-N-acetylglucosamine 2-epimerase

In enzymology, an UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine UDP-N-acetyl-D-mannosamine
UDP-N-acetylglucosamine 2-epimerase
Identifiers
EC number5.1.3.14
CAS number9037-71-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
UDP-N-acetylglucosamine 2-epimerase
crystal structure of udp-n-acetylglucosamine_2 epimerase
Identifiers
SymbolEpimerase_2
PfamPF02350
Pfam clanCL0113
InterProIPR003331
SCOP21f6d / SCOPe / SUPFAM
CDDcd03786

Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-mannosamine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 2-epimerase. Other names in common use include UDP-N-acetylglucosamine 2'-epimerase, uridine diphosphoacetylglucosamine 2'-epimerase, uridine diphospho-N-acetylglucosamine 2'-epimerase, and uridine diphosphate-N-acetylglucosamine-2'-epimerase. This enzyme participates in aminosugars metabolism.

In microorganisms this epimerase is involved in the synthesis of the capsule precursor UDP-ManNAcA.[1][2] An inhibitor of the bacterial 2-epimerase, epimerox, has been described. Some of these enzymes are bifunctional. The UDP-N-acetylglucosamine 2-epimerase from rat liver displays both epimerase and kinase activity.[3]

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1F6D, 1O6C, 1V4V, and 1VGV.

References

Further reading

  • Kikuchi K, Tsuiki S (1973). "Purification and properties of UDP-N-acetylglucosamine 2'-epimerase from rat liver". Biochim. Biophys. Acta. 327 (1): 193–206. doi:10.1016/0005-2744(73)90117-4. PMID 4770741.
This article incorporates text from the public domain Pfam and InterPro: IPR003331


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