3-deoxy-D-manno-octulosonic acid kinase
3-deoxy-D-manno-octulosonic acid kinase (EC 2.7.1.166, kdkA (gene), Kdo kinase) is an enzyme with systematic name ATP:(KDO)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- alpha-Kdo-(2->6)-lipid IVA + ATP 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP
| 3-deoxy-D-manno-octulosonic acid kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.166 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme phosphorylates the 4-OH position of KDO in (KDO)-lipid IVA.
References
- Brabetz W, Müller-Loennies S, Brade H (November 2000). "3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli". The Journal of Biological Chemistry. 275 (45): 34954–62. doi:10.1074/jbc.M005204200. PMID 10952982.
- Harper M, Boyce JD, Cox AD, St Michael F, Wilkie IW, Blackall PJ, Adler B (August 2007). "Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases". Infection and Immunity. 75 (8): 3885–93. doi:10.1128/IAI.00212-07. PMC 1952014. PMID 17517879.
- White KA, Kaltashov IA, Cotter RJ, Raetz CR (June 1997). "A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae". The Journal of Biological Chemistry. 272 (26): 16555–63. doi:10.1074/jbc.272.26.16555. PMID 9195966.
- White KA, Lin S, Cotter RJ, Raetz CR (October 1999). "A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence". The Journal of Biological Chemistry. 274 (44): 31391–400. doi:10.1074/jbc.274.44.31391. PMID 10531340.
External links
- 3-deoxy-D-manno-octulosonic+acid+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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