PFKP

Phosphofructokinase, platelet, also known as PFKP is an enzyme which in humans is encoded by the PFKP gene.[5]

PFKP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPFKP, ATP-PFK, PFK-C, PFK-P, PFKF, phosphofructokinase, platelet
External IDsOMIM: 171840 MGI: 1891833 HomoloGene: 20579 GeneCards: PFKP
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p15.2Start3,066,333 bp[1]
End3,137,718 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5214

56421

Ensembl

ENSG00000067057

ENSMUSG00000021196

UniProt

Q01813

Q9WUA3

RefSeq (mRNA)

NM_001291071
NM_019703

RefSeq (protein)

NP_001278000
NP_062677

Location (UCSC)Chr 10: 3.07 – 3.14 MbChr 13: 6.58 – 6.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose 6-phosphate to fructose 1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM) and liver (PFKL) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phosphofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[5][6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

  1. GRCh38: Ensembl release 89: ENSG00000067057 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021196 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PFKP phosphofructokinase, platelet".
  6. Vora S (April 1981). "Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system". Blood. 57 (4): 724–32. doi:10.1182/blood.V57.4.724.724. PMID 6451249.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q01813 (Human ATP-dependent 6-phosphofructokinase, platelet type) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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