CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
In enzymology, a CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) is an enzyme that catalyzes the chemical reaction
- CDP-diacylglycerol + sn-glycerol 3-phosphate CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
| CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.8.5 | ||||||||
| CAS number | 9068-49-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are CDP-diacylglycerol and sn-glycerol 3-phosphate, whereas its two products are CMP and 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase. Other names in common use include glycerophosphate phosphatidyltransferase, 3-phosphatidyl-1'-glycerol-3'-phosphate synthase, CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol, (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase, phosphatidylglycerophosphate synthase, phosphatidylglycerolphosphate synthase, PGP synthase, CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase, CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase, glycerol phosphate phosphatidyltransferase, glycerol 3-phosphate phosphatidyltransferase, phosphatidylglycerol phosphate synthase, phosphatidylglycerol phosphate synthetase, phosphatidylglycerophosphate synthetase, and sn-glycerol-3-phosphate phosphatidyltransferase. This enzyme participates in glycerophospholipid metabolism.
References
- Bleasdale JE, Johnston JM (1982). "CMP-dependent incorporation of [14C]Glycerol 3-phosphate into phosphatidylglycerol and phosphatidylglycerol phosphate by rabbit lung microsomes". Biochim. Biophys. Acta. 710 (3): 377–90. doi:10.1016/0005-2760(82)90121-7. PMID 7074121.
- Hirabayashi T, Larson TJ, Dowhan W (1976). "Membrane-associated phosphatidylglycerophosphate synthetase from Escherichia coli: purification by substrate affinity chromatography on cytidine 5'-diphospho-1,2-diacyl-sn-glycerol sepharose". Biochemistry. 15 (24): 5205–11. doi:10.1021/bi00669a002. PMID 793612.