ACER2

ACER2
Identifiers
Aliases	ACER2, ALKCDase2, ASAH3L, alkaline ceramidase 2
External IDs	OMIM: 613492 MGI: 1920932 HomoloGene: 14986 GeneCards: ACER2
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	19,452,505 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	86,934,822 bp[2]
Gene ontology
Molecular function	• dihydroceramidase activity; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; • hydrolase activity; • acylsphingosine deacylase activity; • ceramidase activity; • metal ion binding;
Cellular component	• integral component of membrane; • integral component of Golgi membrane; • Golgi apparatus; • membrane; • Golgi membrane;
Biological process	• positive regulation of cell death; • response to retinoic acid; • ceramide metabolic process; • lipid metabolism; • sphingosine biosynthetic process; • sphingolipid biosynthetic process; • negative regulation of cell-matrix adhesion; • cellular response to drug; • positive regulation of cell proliferation; • negative regulation of protein glycosylation in Golgi; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of cell adhesion mediated by integrin; • cellular response to DNA damage stimulus; • regulation of autophagy; • DNA damage response, signal transduction by p53 class mediator; • regulation of apoptotic process; • ceramide catabolic process; • sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	340485
	230379
	ENSG00000177076
	ENSMUSG00000038007
	Q5QJU3
	Q8VD53
	NM_001010887
	NM_001290541; NM_001290543; NM_139306
	NP_001010887
	NP_001277470; NP_001277472; NP_647467
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.[5]

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.[6]

References

GRCh38: Ensembl release 89: ENSG00000177076 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038007 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.
Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876.

External links

Human ACER2 genome location and ACER2 gene details page in the UCSC Genome Browser.

Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153. S2CID 20973940.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177076 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038007 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18619555-5] Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.

[pmid18945876-6] Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876.

ACER2

Function

References

External links

Further reading