Ceramide glucosyltransferase

Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebroside.[1]

Ceramide glucosyltransferase
Identifiers
EC number2.4.1.80
CAS number37237-44-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

It is classified under EC 2.4.1.80.

It is inhibited by miglustat and eliglustat, both drugs developed for the treatment of Gaucher disease.

See also

References

  1. Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (May 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4638–43. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.
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