Ceramide glucosyltransferase
Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebroside.[1]
Ceramide glucosyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.4.1.80 | ||||||||
CAS number | 37237-44-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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It is classified under EC 2.4.1.80.
It is inhibited by miglustat and eliglustat, both drugs developed for the treatment of Gaucher disease.
See also
References
- Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (May 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4638–43. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.
External links
- Ceramide+glucosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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