Apolipoprotein C-II

Apolipoprotein C-II or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene.

APOC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPOC2, APO-CII, APOC-II, apolipoprotein C2
External IDsOMIM: 608083 MGI: 88054 HomoloGene: 47928 GeneCards: APOC2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.32Start44,945,971 bp[1]
End44,949,566 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

344

11813

Ensembl

ENSG00000234906

ENSMUSG00000002992

UniProt

P02655

Q05020

RefSeq (mRNA)

NM_000483

NM_001277944
NM_001309795

RefSeq (protein)

NP_000474
NP_000474.2

NP_001296728
NP_001264873
NP_001296724

Location (UCSC)Chr 19: 44.95 – 44.95 MbChr 7: 19.67 – 19.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Apo-CII
nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
SymbolApo-CII
PfamPF05355
InterProIPR008019
SCOP21by6 / SCOPe / SUPFAM

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,[5] which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000234906 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002992 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153.
  6. "Entrez Gene: APOC2 apolipoprotein C-II".
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