Arrestin beta 2

Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.

ARRB2
Identifiers
Aliases	ARRB2, ARB2, ARR2, BARR2, Arrestin beta 2
External IDs	OMIM: 107941 MGI: 99474 HomoloGene: 3183 GeneCards: ARRB2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,710,596 bp[1] End 4,721,499 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.99 cM Start 70,432,635 bp[2] End 70,440,828 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • alpha-1B adrenergic receptor binding • 14-3-3 protein binding • protein kinase B binding • GO:0001948 protein binding • enzyme binding • angiotensin receptor binding • GO:0032947 molecular adaptor activity • receptor binding • G-protein coupled receptor binding • ubiquitin protein ligase binding • identical protein binding • arrestin family protein binding • GO:0032403 macromolecular complex binding • protein domain specific binding • alpha-1A adrenergic receptor binding • type 1 angiotensin receptor binding • D1 dopamine receptor binding • follicle-stimulating hormone receptor binding • type 2A serotonin receptor binding • platelet activating factor receptor binding • mitogen-activated protein kinase binding Cellular component • cytoplasm • cytosol • postsynaptic membrane • GO:0097483, GO:0097481 postsynaptic density • membrane • cell membrane • endocytic vesicle • dendritic spine • intracellular • basolateral plasma membrane • clathrin-coated pit • cytoplasmic vesicle • cell nucleus • intracellular membrane-bounded organelle • endosome Biological process • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of calcium ion transport • regulation of protein phosphorylation • negative regulation of interleukin-1 beta production • negative regulation of protein kinase B signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein kinase B signaling • positive regulation of protein phosphorylation • endocytosis • regulation of G-protein coupled receptor protein signaling pathway • positive regulation of receptor internalization • negative regulation of release of cytochrome c from mitochondria • negative regulation of interleukin-6 production • receptor internalization • transcription from RNA polymerase II promoter • positive regulation of peptidyl-serine phosphorylation • detection of temperature stimulus involved in sensory perception of pain • follicle-stimulating hormone signaling pathway • platelet activation • dopamine receptor signaling pathway • negative regulation of protein ubiquitination • brain development • GO:0034259 negative regulation of GTPase activity • negative regulation of toll-like receptor signaling pathway • protein ubiquitination • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell chemotaxis • protein transport • negative regulation of natural killer cell mediated cytotoxicity • regulation of androgen receptor signaling pathway • positive regulation of synaptic transmission, dopaminergic • negative regulation of tumor necrosis factor production • negative regulation of signal transduction • positive regulation of protein ubiquitination • transforming growth factor beta receptor signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of smooth muscle cell apoptotic process • desensitization of G-protein coupled receptor protein signaling pathway by arrestin • signal transduction • adult walking behavior • negative regulation of interleukin-12 production • Wnt signaling pathway, planar cell polarity pathway • negative regulation of protein phosphorylation • G-protein coupled receptor internalization • positive regulation of gene expression • protein deubiquitination • membrane organization • positive regulation of cardiac muscle cell differentiation • G-protein coupled receptor signaling pathway • excitatory postsynaptic potential • positive regulation of collagen biosynthetic process • negative regulation of neuron apoptotic process • positive regulation of epithelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	409	216869
Ensembl	ENSG00000141480	ENSMUSG00000060216
UniProt	P32121	Q91YI4
RefSeq (mRNA)	NM_001257328 NM_001257329 NM_001257330 NM_001257331 NM_004313 NM_199004 NM_001330064	NM_001271358 NM_001271359 NM_001271360 NM_145429
RefSeq (protein)	NP_001244257 NP_001244258 NP_001244259 NP_001244260 NP_001316993 NP_004304 NP_945355	NP_001258287 NP_001258288 NP_001258289 NP_663404
Location (UCSC)	Chr 17: 4.71 – 4.72 Mb	Chr 11: 70.43 – 70.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,[5][6][7] as well as having signalling roles in their own right.[8][9][10][11][12] Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[13]

The protein may interact with the agonist DOI in 5-HT_2A receptor signaling.[14][15]

Arrestin beta 2 is crucial for the development of tolerance to morphine and other opioids.