TSPAN3

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.[5]

TSPAN3
Identifiers
AliasesTSPAN3, TM4-A, TM4SF8, TSPAN-3, tetraspanin 3
External IDsOMIM: 613134 MGI: 1928098 HomoloGene: 21168 GeneCards: TSPAN3
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q24.3Start77,041,404 bp[1]
End77,083,984 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10099

56434

Ensembl

ENSG00000140391

ENSMUSG00000032324

UniProt

O60637

Q9QY33

RefSeq (mRNA)

NM_198902
NM_001168412
NM_005724

NM_019793

RefSeq (protein)

NP_001161884
NP_005715
NP_944492

NP_062767

Location (UCSC)Chr 15: 77.04 – 77.08 MbChr 9: 56.13 – 56.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000140391 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032324 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TSPAN3 tetraspanin 3".

Further reading


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