CD53

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.[4][5]

CD53
Identifiers
AliasesCD53, MOX44, TSPAN25, CD53 molecule
External IDsOMIM: 151525 MGI: 88341 HomoloGene: 20152 GeneCards: CD53
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p13.3Start110,871,188 bp[1]
End110,899,922 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

963

12508

Ensembl

ENSG00000143119

ENSMUSG00000040747

UniProt

P19397

Q61451

RefSeq (mRNA)

NM_000560
NM_001040033
NM_001320638

NM_007651

RefSeq (protein)

NP_000551
NP_001035122
NP_001307567

NP_031677

Location (UCSC)Chr 1: 110.87 – 110.9 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000143119 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Korinek V, Horejsi V (Jul 1993). "Genomic structure of the human CD53 gene". Immunogenetics. 38 (4): 272–279. doi:10.1007/BF00188803. PMID 8319976. S2CID 6683727.
  5. "Entrez Gene: CD53 CD53 molecule".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.