CAPN1

Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene.[5][6][7]

CAPN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
External IDsOMIM: 114220 MGI: 88263 HomoloGene: 3800 GeneCards: CAPN1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,180,566 bp[1]
End65,212,006 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

823

12333

Ensembl

ENSG00000014216

ENSMUSG00000024942

UniProt

P07384

O35350

RefSeq (mRNA)

NM_001198868
NM_001198869
NM_005186

NM_001110504
NM_007600

RefSeq (protein)

NP_001185797
NP_001185798
NP_005177

NP_001103974
NP_031626

Location (UCSC)Chr 11: 65.18 – 65.21 MbChr 19: 5.99 – 6.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.[7]

Interactions

CAPN1 has been shown to interact with PSEN2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000014216 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024942 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Aoki K, Imajoh S, Ohno S, Emori Y, Koike M, Kosaki G, Suzuki K (Oct 1986). "Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence". FEBS Lett. 205 (2): 313–7. doi:10.1016/0014-5793(86)80919-X. PMID 3017764. S2CID 36697759.
  6. Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K (Nov 1990). "Four genes for the calpain family locate on four distinct human chromosomes". Cytogenet Cell Genet. 53 (4): 225–9. doi:10.1159/000132937. PMID 2209092.
  7. "Entrez Gene: CAPN1 calpain 1, (mu/I) large subunit".
  8. Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K (1998). "The presenilin 2 loop domain interacts with the mu-calpain C-terminal region". Int. J. Mol. Med. 1 (5): 797–9. doi:10.3892/ijmm.1.5.797. PMID 9852298.

Further reading


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