Cathepsin L2

Cathepsin L2, also known as cathepsin V and encoded by the CTSV gene, is a human gene.[5]

CTSV
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSV, cathepsin V, CATL2, CTSL2, CTSU
External IDsOMIM: 603308 MGI: 88564 HomoloGene: 76699 GeneCards: CTSV
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q22.33Start97,029,677 bp[1]
End97,039,643 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1515

13039

Ensembl

ENSG00000136943

ENSMUSG00000021477

UniProt

O60911

P06797

RefSeq (mRNA)

NM_001333
NM_001201575

NM_009984

RefSeq (protein)

NP_001188504
NP_001324

NP_034114

Location (UCSC)Chr 9: 97.03 – 97.04 MbChr 13: 64.36 – 64.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Clinical significance

Cathepsin L2 may play a role in the pathogenesis of keratoconus.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000136943 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021477 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CTSL2 cathepsin L2".
  6. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ (2005). "Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder". Invest. Ophthalmol. Vis. Sci. 46 (3): 823–832. doi:10.1167/iovs.04-0549. PMID 15728537.
  • The MEROPS online database for peptidases and their inhibitors: C01.009

Further reading


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