Cathepsin W

Cathepsin W is a protein that in humans is encoded by the CTSW gene.[4][5][6]

CTSW
Identifiers
AliasesCTSW, LYPN, cathepsin W
External IDsOMIM: 602364 MGI: 1338045 HomoloGene: 37471 GeneCards: CTSW
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,879,837 bp[1]
End65,883,741 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1521

13041

Ensembl

ENSG00000172543

ENSMUSG00000024910

UniProt

P56202

P56203

RefSeq (mRNA)

NM_001335

NM_009985

RefSeq (protein)

NP_001326

NP_034115

Location (UCSC)Chr 11: 65.88 – 65.88 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Linnevers C, Smeekens SP, Bromme D (May 1997). "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett. 405 (3): 253–9. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299. S2CID 45420314.
  5. Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D (Aug 1998). "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun. 248 (2): 255–61. doi:10.1006/bbrc.1998.8954. PMID 9675123.
  6. "Entrez Gene: CTSW cathepsin W".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: C01.037


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