COP9 constitutive photomorphogenic homolog subunit 5

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.[5]

COPS5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPS5, CSN5, JAB1, MOV-34, SGN5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome subunit 5
External IDsOMIM: 604850 MGI: 1349415 HomoloGene: 55992 GeneCards: COPS5
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q13.1Start67,043,079 bp[1]
End67,083,783 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10987

26754

Ensembl

ENSG00000121022

ENSMUSG00000025917

UniProt

Q92905

O35864

RefSeq (mRNA)

NM_006837

NM_001277101
NM_013715

RefSeq (protein)

NP_006828
NP_006828.2

NP_001264030
NP_038743

Location (UCSC)Chr 8: 67.04 – 67.08 MbChr 1: 10.02 – 10.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.[5]

Interactions

COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,[6][7] GFER,[8] BCL3,[9] Ubiquitin carboxy-terminal hydrolase L1,[10] S100A7[11] and C-jun.[12]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000121022 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025917 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)".
  6. Ghosh S, Leaton LA, Farr L, Barfield A, Moonah S (July 2018). "Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function". Scientific Reports. 8 (1): 10241. doi:10.1038/s41598-018-28625-1. PMC 6035221. PMID 29980718.
  7. Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, et al. (November 2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. 408 (6809): 211–6. doi:10.1038/35041591. PMID 11089976. S2CID 205010648.
  8. Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, et al. (January 2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB Journal. 16 (1): 90–2. doi:10.1096/fj.01-0506fje. PMID 11709497. S2CID 7006611.
  9. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, et al. (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
  10. Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, et al. (May 2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. doi:10.1038/sj.onc.1205390. PMID 12082530.
  11. Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH (April 2003). "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Research. 63 (8): 1954–61. PMID 12702588.
  12. Claret FX, Hibi M, Dhut S, Toda T, Karin M (October 1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature. 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781. S2CID 4353893.

Further reading

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