Carboxymethyloxysuccinate lyase

In enzymology, a carboxymethyloxysuccinate lyase (EC 4.2.99.12) is an enzyme that catalyzes the chemical reaction

carboxymethyloxysuccinate fumarate + glycolate
carboxymethyloxysuccinate lyase
Identifiers
EC number4.2.99.12
CAS number53167-89-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, carboxymethyloxysuccinate, and two products, fumarate and glycolate.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that cleave carbon-oxygen bonds. The systematic name of this enzyme class is carboxymethyloxysuccinate glycolate-lyase (fumarate-forming). Other names in common use include carbon-oxygen lyase, and carboxymethyloxysuccinate glycolate-lyase.

References

    • Peterson D, Llaneza J (1974). "Identification of a carbon-oxygen lyase activity cleaving the ether linkage in carboxymethyloxysuccinic acid". Arch. Biochem. Biophys. 162 (1): 135–46. doi:10.1016/0003-9861(74)90112-X. PMID 4831330.


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