Cisterna

A cisterna (plural cisternae) is a flattened membrane vesicle of the endoplasmic reticulum and Golgi apparatus. A Golgi stack may contain anywhere from three to twenty cisternae, but most contain about six cisternae. Golgi cisternae can be separated into four classes; cis, medial, trans, and TGN (trans-Golgi network).[1] Each type of cisterna contains different enzymes to prevent any redundant enzymatic activity.[1] Almost all cisternae in the Golgi apparatus exhibit multiple stacking. However, there are evolutionary lineages in which the stacked characteristic has been lost.[2]

For other uses, see Cisterna (disambiguation).

In plants, stacks of cisternae are known as dictyosomes.[3]

Function

Cisternae pack and modify proteins and polysaccharides. Biosynthetic cargo proteins travel through cisternae and undergo glycan remodeling and other modifications. Cisternae pack the proteins and then send them to transport carriers. They also pack polysaccharides that are synthesized in the Golgi apparatus. The compounds enter at the cis face of the Golgi stack and exit out the trans side where most of the packaging occurs.[1]

The functions of cisternae change as it undergoes micromaturation. Immature cisternae receive COPII vesicles from the endoplasmic reticulum.[4] During this stage, new cisternae can be produced. The next stage begins when cisternae at carbohydrate synthesis swap material via COPI vesicles. This is when glycosylation and polysaccharide synthesis occur. Mature cisternae reach the final stage where cargo proteins are sent to transport carriers and finally the cisternae disassemble.[1]

References
  1. Day, Kasey J.; Staehelin, L. Andrew; Glick, Benjamin S. (2013-07-24). "A three-stage model of Golgi structure and function". Histochemistry and Cell Biology. 140 (3): 239–249. doi:10.1007/s00418-013-1128-3. ISSN 0948-6143. PMC 3779436. PMID 23881164.
  2. Klute, Mary J.; Melançon, Paul; Dacks, Joel B. (2011-08-01). "Evolution and Diversity of the Golgi". Cold Spring Harbor Perspectives in Biology. 3 (8): a007849. doi:10.1101/cshperspect.a007849. ISSN 1943-0264. PMC 3140683. PMID 21646379.
  3. "Definition of DICTYOSOME". www.merriam-webster.com. Retrieved 2019-12-08.
  4. Bankaitis, Vytas A.; Garcia-Mata, Rafael; Mousley, Carl J. (2012-05-22). "Golgi Membrane Dynamics and Lipid Metabolism". Current Biology. 22 (10): R414–R424. doi:10.1016/j.cub.2012.03.004. ISSN 0960-9822. PMC 4059015. PMID 22625862.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.