Cone snail

There are over 900 different species of cone snails.[6] Cone snails are typically found in warm and tropical seas and oceans worldwide, and they reach their greatest diversity in the Western Indo-Pacific region. However, some species are adapted to temperate/semi tropical environments, such as the Cape coast of South Africa,[7][8] the Mediterranean,[9] or the cool subtropical waters of southern California (Conus californicus),[10] and are endemic to these areas.

Cone snails are found in all tropical and subtropical seas, from the intertidal zone to deeper areas, living on sand or among rocks or coral reefs. When living on sand, these snails bury themselves with only the siphon protruding from the surface. Many tropical cone snails live in or near coral reefs. Some species are found under rocks in the lower intertidal and shallow subtidal zones. They can be incredibly deadly.

This group of sea snails shows a large variety of colors and patterns, and local varieties and color forms of the same species often occur. This has led to the creation of a large number of known synonyms and probable synonyms, making it difficult to give an exact taxonomic assignment for many snails in this genus. As of 2009, more than 3,200 different species names have been assigned, with an average of 16 new species names introduced each year.[11]

The shells of cone snails vary in size. The shells are shaped more or less like the geometric shape known as a cone, as one might expect from the popular and scientific name. The shell is many-whorled and in the form of an inverted cone, the anterior end being the narrow end. The protruding parts of the top of the whorls that form the spire are more or less in the shape of another, much more flattened, cone. The aperture is elongated and narrow. The horny operculum is very small. The outer lip is simple, thin, and sharp, is without a callus, and has a notched tip at the upper part. The columella is straight.

The larger species of cone snails can grow up to 23 cm (9.1 in) in length. The shells of cone snails are often brightly colored and have interesting patterns, although in some species the color patterns may be partially or completely hidden under an opaque layer of periostracum. In other species, the topmost shell layer is thin periostracum, a transparent yellowish or brownish membrane.

Cone snails are carnivorous and predatory. They hunt and eat prey such as marine worms, small fish, molluscs, and even other cone snails. Because cone snails are slow-moving, they use a venomous harpoon (called a toxoglossan radula) to capture faster-moving prey, such as fish. The venom of a few larger species, especially the piscivorous ones, is powerful enough to kill a human.

The osphradium (a chemoreceptory organ) is more highly specialized than the same organ in any other group of gastropods. It is through this sensory modality that cone snails become aware of the presence of a prey animal, not through vision. The cone snails immobilize their prey using a modified, dartlike, barbed radular tooth, made of chitin, along with a venom gland containing neurotoxins. Small species of these cone snails hunt small prey, such as marine worms, whereas larger cone snails hunt fish.

Molecular phylogeny research by Kraus et al. (2010)[12] based on a part of "intron 9" of the gamma-glutamyl carboxylase gene has shown that feeding on fish has evolved at least twice independently in the group.

Harpoon and venoms

An individual Conus pennaceus attacking one of a cluster of three snails of the species Cymatium nicobaricum, in Hawaii

Cone snails use a radula tooth as a harpoon-like structure for predation. Each of these harpoons is a modified tooth, primarily made of chitin and formed inside the mouth of the snail, in a structure known as the toxoglossan radula. (The radula in most gastropods has rows of many small teeth, and is used for grasping at food and scraping it into the mouth.) Each specialized cone snail tooth is stored in the radula sac (an everted pocket in the posterior wall of the buccal cavity), except the tooth that is currently ready to be used. The radular-tooth structures differ slightly according to the feeding mode of vermivorous, molluscivorous and piscivorous species.[13]

The tooth is hollow and barbed, and is attached to the tip of the radula in the radular sac, inside the snail's throat. When the snail detects a prey animal nearby, it extends a long flexible tube called a proboscis towards the prey. The radula tooth is loaded with venom from the venom bulb and, still attached to the radula, is fired from the proboscis into the prey by a powerful muscular contraction. The venom paralyzes small fish almost instantly. The snail then retracts the radula, drawing the subdued prey into the mouth. After the prey has been digested, the cone snail will regurgitate any indigestible material, such as spines and scales, along with the then-disposable harpoon. There is always a dart stored in the radular sac. A dart may be used in self-defense when the snail feels threatened.[14][15]

The venom of cone snails contains hundreds of different compounds, and its exact composition varies widely from one species to another. The toxins in these various venoms are called conotoxins. These are various peptides, each targeting a specific nerve channel or receptor. Some cone snail venoms also contain a pain-reducing toxin, which the snail uses to pacify the victim before immobilising and then killing it.

Prior to 2009, all species within the family Conidae were still placed in one genus Conus. Testing in order to try to understand the molecular phylogeny of the Conidae was initially begun by Christopher Meyer and Alan Kohn,[29] and is continuing, particularly with the advent of nuclear DNA testing in addition to mDNA testing.

In 2009, J.K. Tucker and M.J. Tenorio proposed a classification system consisting of three distinct families and 82 genera for the living species of cone snails. This classification was based on shell morphology, radular differences, anatomy, physiology, and cladistics, with comparisons to molecular (DNA) studies.[30] Published accounts of genera within the Conidae that use these new genera include J.K. Tucker & M.J. Tenorio (2009), and Bouchet et al. (2011).[31] Tucker and Tenorio's proposed classification system for the cone shells and their allies (and the other clades of Conoidean gastropods) is shown in Tucker & Tenorio cone snail taxonomy 2009.

Some experts, however, preferred to use the traditional classification, where all species are placed in Conus within the single family Conidae: for example, according to the November 2011 version of the World Register of Marine Species, all species within the family Conidae were placed in the genus Conus. The binomial names of species in the 82 genera of living cone snails listed in Tucker & Tenorio 2009 were recognized by the World Register of Marine Species as "alternative representations".[32] Debate within the scientific community regarding this issue continued, and additional molecular phylogeny studies were being carried out in an attempt to clarify the issue.[30][33][34][35][36][37][38][39][40][41]

In 2015, in the Journal of Molluscan Studies, Puillandre, Duda, Meyer, Olivera & Bouchet presented a new classification for the old genus Conus. Using 329 species, the authors carried out molecular phylogenetic analyses. The results suggested that the authors should place all cone snails in a single family, Conidae, containing four genera: Conus, Conasprella, Profundiconus and Californiconus. The authors group 85% of all known cone snail species under Conus. They recognize 57 subgenera within Conus, and 11 subgenera within the genus Conasprella.[1]

• ConoServer, a database of cone snail toxins, known as conopeptides.[42] These toxins are of importance to medical research.
• Conotoxin

• SEM images of the radula can be found at Thompson, T.E.; Bebbington, A. (1973). "Scanning electron microscope studies of gastropod radulae". Malacologia. 14: 147–165.
• Tucker J.K. (2009). Recent cone species database. September 4th 2009 Edition
• Filmer R.M. (2001). A Catalogue of Nomenclature and Taxonomy in the Living Conidae 1758–1998. Backhuys Publishers, Leiden. 388pp
• Bouchet, P.; Fontaine, B. (2009). "List of new marine species described between 2002–2006". Census of Marine Life.
• Natural History Museum Rotterdam - photos of Conus shells
• Cone snail and conotoxins page
• The Conus Biodiversity website
• ConoServer
• Conidae from worldwide.conchology.com. Scroll down for many photographs.
• Pain-killer comes out of its shell (The Age news article)
• Venomous snails aid medical science (BBC News Article).
• ConeShell Collection Giancarlo Paganelli
• Cone Shells - Knights of the Sea. Alexander Medvedev's collection
• Cone Snail Video - Hunting Footage and Physiology
• Deadly Critters That Might Save Your Life (CNN)
• Baldomero "Toto" Olivera's short talk: Conus Peptides
• Zonatus Gallery
• Miller, John A. (1989). "The toxoglossan proboscis: structure and function". Journal of Molluscan Studies. 55 (2): 167–181. doi:10.1093/mollus/55.2.167.
• BBC Nature Video Cone snails are silent assassins of the sea, drugging sleeping fish before poisoning them