Congenital sensorineural deafness in cats

Congenital sensorineural deafness occurs commonly in domestic cats with a white coat. It is a congenital deafness caused by a degeneration of the inner ear.[1] Deafness is far more common in white cats than in those with other coat colours. According to the ASPCA Complete Guide to Cats, "17 to 20 percent of white cats with nonblue eyes are deaf; 40 percent of "odd-eyed" white cats with one blue eye are deaf; and 65 to 85 percent of blue-eyed white cats are deaf."[2]

A completely deaf, pure white, blue-eyed cat
Deaf odd-eyed white cat

Domesticated cats with blue eyes and white coats are often completely deaf.[3] Deafness can occur in white cats with yellow, green or blue irises, although it is mostly likely in white cats with blue irises.[4] In white cats with mixed-coloured eyes (odd-eyed cats), it has been found that deafness is more likely to affect the ear on the blue-eyed side.[1] White cats can have blue, gold, green or copper coloured odd eyes.

In one 1997 study of white cats, 72% of the animals were found to be totally deaf. The entire organ of Corti in the cochlea was found to have degenerated in the first few weeks after birth; however, even during these weeks no brain stem responses could be evoked by auditory stimuli, suggesting that these animals had never experienced any auditory sensations. It was found that some months after the organ of Corti had degenerated, the spiral ganglion of the cochlea also began to degenerate.[5]

Genetics

Although few studies have been done to link this to genes known to be involved in human Waardenburg syndrome, a syndrome of hearing loss and depigmentation caused by a genetic disruption to neural crest cell development, such a disruption would lead to this presentation in cats as well.[6] Waardenburg syndrome type 2A (caused by a mutation in MITF) has been found in many other small mammals including dogs, minks and mice, and they all display at least patchy white depigmentation and some degeneration of the cochlea and saccule, as in deaf white cats.[7][8]

A major gene that causes a cat to have a white coat is a dominant masking gene, an allele of KIT which suppresses pigmentation and hearing. The cat would have an underlying coat colour and pattern, but when the dominant white gene is present, that pattern will not be expressed, and the cat will be deaf. A cat that is homozygous (WW) or heterozygous (Ww) for this gene will have a white coat despite the underlying pattern/colour. A cat that lacks this dominant masking gene (ww) will exhibit a coat colour/pattern.[9] KIT mutations have also led to patchy depigmentation and different coloured irises in humans,[10] and KIT has been found to increase MITF expression, the gene involved in human Waardenburg syndrome type 2A.[11]

A white cat may have blue eyes for reasons other than masking. If the underlying coat pattern is one of a pointed cat (also referred to as a Siamese pattern), the blue eyes may come from the genetics of the pointed gene.

A common misconception is that all white cats with blue eyes are deaf.[12] It is possible to have a cat with a naturally white coat without this gene, as an extreme form of white spotting, although this is rare – some small non-white patch usually remains.

  • The character Snowkit in Warriors: A Dangerous Path has congential sensorineural deafness.[13] His condition leads to his death as he fails to hear his mother's warning of the appearance of a predator.[14]

See also

References
  1. Bosher, SK; Hallpike, CS (13 April 1965). "Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat". Proceedings of the Royal Society B: Biological Sciences. 162 (987): 147–170. Bibcode:1965RSPSB.162..147B. doi:10.1098/rspb.1965.0030. PMID 14285813. S2CID 36675534.
  2. Richards J (1999). ASPCA Complete Guide to Cats: Everything You Need to Know About Choosing and Caring for Your Pet. Chronicle Books. p. 71. ISBN 9780811819299.
  3. Webb AA, Cullen CL (June 2010). "Coat color and coat color pattern-related neurologic and neuro-ophthalmic diseases". Can. Vet. J. 51 (6): 653–7. PMC 2871368. PMID 20808581.
  4. "Ask Elizabeth: White Cats and Blindness/Deafness". Cornell University College of Veterinary Medicine. Cornell University College of Veterinary Medicine Ithaca, New York. Retrieved 3 December 2016.
  5. Heid, S; Hartmann, R; Klinke, R (January 1998). "A model for prelingual deafness, the congenitally deaf white cat—population statistics and degenerative changes". Hearing Research. 115 (1–2): 101–12. doi:10.1016/S0378-5955(97)00182-2. PMID 9472739. S2CID 38262220.
  6. Omenn, Gilbert S.; McKusick, Victor A.; Gorlin, Robert J. (1979). "The association of Waardenburg syndrome and Hirschsprung megacolon". American Journal of Medical Genetics. 3 (3): 217–223. doi:10.1002/ajmg.1320030302. ISSN 1096-8628. PMID 484594.
  7. MARKAKIS, MARIOS N.; SOEDRING, VIBEKE E.; DANTZER, VIBEKE; CHRISTENSEN, KNUD; ANISTOROAEI, RAZVAN (2014-08-01). "Association of MITF gene with hearing and pigmentation phenotype in Hedlund white American mink (Neovison vison)". Journal of Genetics. 93 (2): 477–481. doi:10.1007/s12041-014-0370-3. hdl:10067/1211550151162165141. ISSN 0973-7731. PMID 25189243. S2CID 16725018.
  8. Strain, George M. (2015). "The Genetics of Deafness in Domestic Animals". Frontiers in Veterinary Science. 2: 29. doi:10.3389/fvets.2015.00029. ISSN 2297-1769. PMC 4672198. PMID 26664958.
  9. David, Victor A.; Menotti-Raymond, Marilyn; Wallace, Andrea Coots; Roelke, Melody; Kehler, James; Leighty, Robert; Eizirik, Eduardo; Hannah, Steven S.; Nelson, George; Schäffer, Alejandro A.; Connelly, Catherine J. (2014-10-01). "Endogenous Retrovirus Insertion in the KIT Oncogene Determines White and White spotting in Domestic Cats". G3: Genes, Genomes, Genetics. 4 (10): 1881–1891. doi:10.1534/g3.114.013425. ISSN 2160-1836. PMC 4199695. PMID 25085922.
  10. Hamadah, Issam; Chisti, Muzamil; Haider, Mansoor; Al Dosssari, Haya; Alhumaidan, Rawan; Meyer, Brian F.; Wakil, Salma M. (2019-07-13). "A novel KIT mutation in a family with expanded syndrome of piebaldism". JAAD Case Reports. 5 (7): 627–631. doi:10.1016/j.jdcr.2019.01.021. ISSN 2352-5126. PMC 6630042. PMID 31341943.
  11. Lee, Youl-Nam; Brandal, Stephanie; Noel, Pierre; Wentzel, Erik; Mendell, Joshua T.; McDevitt, Michael A.; Kapur, Reuben; Carter, Melody; Metcalfe, Dean D.; Takemoto, Clifford M. (2011-03-31). "KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation". Blood. 117 (13): 3629–3640. doi:10.1182/blood-2010-07-293548. ISSN 0006-4971. PMC 3072881. PMID 21273305.
  12. George M. Strain (2011). Deafness in Dogs and Cats. CABI. pp. 68. ISBN 978-1-84593-764-5.
  13. Hunter, Erin. A Dangerous Path. Harper Children's. p. 79-81. ISBN 9780062367006.
  14. Hunter, Erin. A Dangerous Path. Harper Children's. p. 94. ISBN 9780062367006.
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