Crystallin, gamma D

Gamma-crystallin D is a protein that in humans is encoded by the CRYGD gene.[5]

CRYGD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRYGD, CACA, CCA3, CCP, CRYG4, CTRCT4, PCC, cry-g-D, crystallin gamma D
External IDsOMIM: 123690 MGI: 88524 HomoloGene: 36213 GeneCards: CRYGD
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.3Start208,121,607 bp[1]
End208,124,524 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1421

12967

Ensembl

ENSG00000118231
ENSG00000285434

ENSMUSG00000067299

UniProt

P07320

P04342

RefSeq (mRNA)

NM_006891

NM_007776

RefSeq (protein)

NP_008822

NP_031802

Location (UCSC)Chr 2: 208.12 – 208.12 MbChr 1: 65.06 – 65.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.[5]

References

  1. ENSG00000285434 GRCh38: Ensembl release 89: ENSG00000118231, ENSG00000285434 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067299 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CRYGD crystallin, gamma D".

Further reading

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