De La Salle University Science and Technology Complex

Milagros R. del Rosario Building is a four-story building and the first building to be constructed on campus, which houses the school's administrative offices and classrooms for the Senior High School. The building was generously given to the school by alumnus and former LSC Yell Commander Ambassador Ramon V. del Rosario of Phinma. The building has 35 classrooms, a 200-seat auditorium, three audio-visual rooms, the College Library, a media lab, a dark room for the photography students, a radio station, a children's playroom, a robotics classroom, physics and chemistry laboratories, engineering laboratories, and three computer laboratories. Construction began in April 2002 and was completed in June 2003 and was designed by the firm L.V. Locsin and Partners.

Beginning construction on August 2005, the Integrated School (IS) building finished right on time for the next school year on March 2006. The IS Building houses the classrooms and other spaces for the Nursery to Grade 4 students of the Integrated School. The building also houses the main school clinic, the IS Office of Sports Development (IS-OSD), and the Parents Association (PA) Office.

On 2013, the three-story LC1 Annex Building was inaugurated. This houses the preschool library and the administration office located at the 3rd floor of the building.

The Pergola is a multi-purpose hall for the students. It stands beside the new Integrated School Building. The covered area acts as a special venue with several functions for the different activities of the Academic Community.

The LC2 Building is the second building near LC1 Annex. This building has a robotics room, a bookstore, a canteen, a clinic, a library, science laboratories, two computer rooms, and an auditorium, and it houses the classrooms for Grade 5 to Grade 10.

Dr. George S.K. Ty Advanced Instrumentation Building is a four-story multi-disciplinary facility that will utilize high-precision equipment for experimental and laboratory works.[3] Also known as Clean Building,[4] it currently houses classrooms for undergraduate students and the DLSU Nuclear Magnetic Resonance (NMR) Laboratory, which is under the office of the DLSU Vice Chancellor for Research and Innovation and considered as one of the country's most sophisticated of its kind.[5][6] It is named after Dr. George S.K. Ty, the chairman of Metrobank Group, who through his family foundation GT Foundation, Inc. (GTFI) pledged ₱100 million for its construction.[7]

Richard L. Lee Engineering and Technology Block is considered as a hub of DLSU's engineering courses.[3] Also known as The Hangar,[4] the building was donated to DLSU in 2014 by Richard Lee, a DLSU alumnus and chairman emeritus of Hyundai Asia Resources, Inc.[8] It was instituted on January 19, 2019.[9]

John L. Gokongwei, Jr. Innovation Center (DLSU-JGIC) is a four-story building that houses the Philippine hub of the French video game company Ubisoft.[3] The building is part of the support of Gokongwei Brothers Foundation’s (GBF) for DLSU and is named after the Filipino-Chinese tycoon John Gokongwei, Jr.[10][11][12]

Slated to become a world-class center for training DLSU's student-athletes and a venue for regional sports tournaments,[3] Laguna Campus's football field is a 100m long by 64m wide football field, surrounded by an IAAF-standard track. The field is the second artificial football pitch in Laguna, after the Biñan Football Stadium.[13]