Deep homology

In 1822, the French zoologist Étienne Geoffroy Saint-Hilaire dissected a crayfish, discovering that its body is organised like a vertebrate's, but inverted belly to back (dorsoventrally):[1]

I just found that all the soft organs, that is to say, the principal organs of life are found in crustaceans, and so in insects, in the same order, in the same relationships and with the same arrangement as their analogues in the high vertebrate animals ... What was my surprise, and I may add, my admiration, seeing [such] a rule ...[1]

Homologous hox genes in such different animals as insects and vertebrates control embryonic development and hence the form of adult bodies. These genes have been highly conserved through hundreds of millions of years of evolution.

Geoffroy's homology theory was denounced by the leading French zoologist of his day, Georges Cuvier, but in 1994, Geoffroy was shown to be correct.[1] In 1915, Santiago Ramon y Cajal mapped the neural connections of the optic lobes of a fly, finding that these resembled those of vertebrates.[1] In 1978, Edward B. Lewis helped to found evolutionary developmental biology, discovering that homeotic genes regulated embryonic development in fruit flies.[1]

In 1997, the term deep homology first appeared in a paper by Neil Shubin, Cliff Tabin, and Sean B. Carroll, describing the apparent relatedness in genetic regulatory apparatuses which indicated evolutionary similarities in disparate animal features.[2]

Whereas ordinary homology is seen in the pattern of structures such as limb bones of mammals that are evidently related, deep homology can apply to groups of animals that have quite dissimilar anatomy: vertebrates (with endoskeletons made of bone and cartilage) and arthropods (with exoskeletons made of chitin) nevertheless have limbs that are constructed using similar recipes or "algorithms".[2][3][4][5]

Within the metazoa, homeotic genes control differentiation along major body axes, and pax genes (especially PAX6) help to control the development of the eye and other sensory organs. The deep homology applies across widely separated groups, such as in the eyes of mammals and the structurally quite different compound eyes of insects.[3]

Similarly, hox genes help to form an animal's segmentation pattern. HoxA and HoxD, that regulate finger and toe formation in mice, control the development of ray fins in zebrafish; these structures had until then been considered non-homologous.[6]

There is a possible deep homology among animals that use acoustic communication, such as songbirds and humans, which may share unmutated versions of the FOXP2 gene.[7]

In 2010, a team led by Edward Marcotte developed an algorithm that identifies deeply homologous genetic modules in unicellular organisms, plants, and animals based on phenotypes (such as traits and developmental defects). The technique aligns phenotypes across organisms based on orthology (a type of homology) of genes involved in the phenotypes.[8][9]

• Body plan – A set of morphological features common to members of a phylum of animals