FFAR2-FFAR3 receptor heteromer
The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.
| free fatty acid receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FFAR2 | ||||||
| Alt. symbols | GPR43, FFA2R | ||||||
| NCBI gene | 2867 | ||||||
| HGNC | 4501 | ||||||
| OMIM | 603823 | ||||||
| RefSeq | NM_005306 | ||||||
| UniProt | O15552 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.1 | ||||||
| |||||||
| free fatty acid receptor 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FFAR3 | ||||||
| Alt. symbols | GPR41, FFA3R | ||||||
| NCBI gene | 2865 | ||||||
| HGNC | 4499 | ||||||
| OMIM | 603821 | ||||||
| RefSeq | NM_005304 | ||||||
| UniProt | O14843 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.1 | ||||||
| |||||||
Signal transduction
The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular calcium release and Arrestin beta 2 recruitment. The heteromer also lacks the ability to inhibit the cAMP-dependent pathway but gained the ability to induce P38 mitogen-activated protein kinases.[1]
References
- Ang Z, Xiong D, Wu M, Ding JL (January 2018). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal. 32 (1): 289–303. doi:10.1096/fj.201700252RR. PMC 5731126. PMID 28883043.
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