Formate dehydrogenase (acceptor)

Formate dehydrogenase (acceptor) (EC 1.1.99.33, FDHH, FDH-H, FDH-O, formate dehydrogenase H, formate dehydrogenase O) is an enzyme with systematic name formate:acceptor oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

formate + acceptor CO2 + reduced acceptor
Formate dehydrogenase (acceptor)
Identifiers
EC number1.1.99.33
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer] transferring electrons to a hydrogenase.

References
  1. Axley MJ, Grahame DA, Stadtman TC (October 1990). "Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component". The Journal of Biological Chemistry. 265 (30): 18213–8. PMID 2211698.
  2. Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD (April 1996). "Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis". The Journal of Biological Chemistry. 271 (14): 8095–100. PMID 8626495.
  3. Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC (March 1998). "Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer". Biochemistry. 37 (10): 3518–28. doi:10.1021/bi972177k. PMID 9521673.
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