Gem-associated protein 6

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.[5][6] The gem-associated proteins are those found in the gems of Cajal bodies.

GEMIN6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGEMIN6, gem nuclear organelle associated protein 6
External IDsOMIM: 607006 MGI: 1914492 HomoloGene: 11711 GeneCards: GEMIN6
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p22.1Start38,751,534 bp[1]
End38,785,002 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79833

67242

Ensembl

ENSG00000152147

ENSMUSG00000055760

UniProt

Q8WXD5

Q9CX53

RefSeq (mRNA)

NM_024775

NM_026053
NM_001355458

RefSeq (protein)

NP_079051

NP_080329
NP_001342387

Location (UCSC)Chr 2: 38.75 – 38.79 MbChr 17: 80.22 – 80.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM][6]

Interactions

Gem-associated protein 6 has been shown to interact with gem-associated protein 7.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000152147 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055760 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
  6. "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

Further reading

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