Glycerol-3-phosphate cytidylyltransferase

In enzymology, a glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) is an enzyme that catalyzes the chemical reaction

CTP + sn-glycerol 3-phosphate diphosphate + CDP-glycerol
glycerol-3-phosphate cytidylyltransferase
Identifiers
EC number2.7.7.39
CAS number9027-11-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are CTP and sn-glycerol 3-phosphate, whereas its two products are diphosphate and CDP-glycerol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:sn-glycerol-3-phosphate cytidylyltransferase. Other names in common use include CDP-glycerol pyrophosphorylase, cytidine diphosphoglycerol pyrophosphorylase, cytidine diphosphate glycerol pyrophosphorylase, CTP:glycerol 3-phosphate cytidylyltransferase, and Gro-PCT. This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1COZ, 1N1D, and 2B7L.

References

    • Shaw DR (February 1962). "Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol". The Biochemical Journal. 82 (2): 297–312. doi:10.1042/bj0820297. PMC 1243453. PMID 13911452.


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