Homospermidine synthase (spermidine-specific)
In enzymology, a homospermidine synthase (spermidine-specific) (EC 2.5.1.45) is an enzyme that catalyzes the chemical reaction
- spermidine + putrescine sym-homospermidine + propane-1,3-diamine
| homospermidine synthase (spermidine-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.45 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are spermidine and putrescine, whereas its two products are sym-homospermidine and propane-1,3-diamine.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming).
References
- Ostrovsky AN, Grischenko AV, Taylor PD, Bock P, Mawatari SF (2006). "Comparative anatomical study of internal brooding in three anascan bryozoans (Cheilostomata) and its taxonomic and evolutionary implications". J. Morphol. 267 (6): 739–49. doi:10.1002/jmor.10438. PMID 16526057.
- Ober D, Hartmann T (1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14777–82. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.
- Ober D, Harms R, Hartmann T (2000). "Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision". Phytochemistry. 55 (4): 311–316. doi:10.1016/S0031-9422(00)00267-3. PMID 11117877.
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