INHBC

INHBC
Identifiers
Aliases	INHBC, IHBC, inhibin beta C, inhibin beta C subunit, inhibin subunit beta C
External IDs	OMIM: 601233 MGI: 105932 HomoloGene: 21142 GeneCards: INHBC
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	57,452,062 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	127,370,431 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• growth factor activity; • transforming growth factor beta receptor binding; • hormone activity; • cytokine activity;
Cellular component	• extracellular region; • extracellular;
Biological process	• positive regulation of pathway-restricted SMAD protein phosphorylation; • regulation of MAPK cascade; • cell development; • regulation of apoptotic process; • SMAD protein signal transduction; • regulation of receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3626
	16325
	ENSG00000175189
	ENSMUSG00000025405
	P55103
	P55104
	NM_005538
	NM_010565
	NP_005529
	NP_034695
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.[5][6]

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.[6]

References

GRCh38: Ensembl release 89: ENSG00000175189 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025405 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun. 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378.
"Entrez Gene: INHBC inhibin, beta C".

Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction". Recent Prog. Horm. Res. 56: 417–50. doi:10.1210/rp.56.1.417. PMID 11237224.
Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase". Cell. 65 (6): 973–82. doi:10.1016/0092-8674(91)90549-E. PMID 1646080. S2CID 36407277.
Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene". Genomics. 32 (3): 358–66. doi:10.1006/geno.1996.0130. PMID 8838799.
Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia". Prostate. 34 (1): 34–43. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386.
Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. doi:10.1210/jc.85.12.4851. PMID 11134153.
Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia". Mol. Hum. Reprod. 9 (4): 199–203. doi:10.1093/molehr/gag029. PMID 12651901.
Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate". Endocrinology. 144 (10): 4410–9. doi:10.1210/en.2003-0225. PMID 12960042.
Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein". J. Reprod. Dev. 52 (4): 487–95. doi:10.1262/jrd.17110. PMID 16627954.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175189 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025405 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7826378-5] H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun. 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378.

[entrez-6] "Entrez Gene: INHBC inhibin, beta C".

INHBC

References

Further reading