BAMBI

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[5][6]

BAMBI
Identifiers
AliasesBAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDsOMIM: 604444 MGI: 1915260 HomoloGene: 8215 GeneCards: BAMBI
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p12.1Start28,677,510 bp[1]
End28,682,932 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

25805

68010

Ensembl

ENSG00000095739

ENSMUSG00000024232

UniProt

Q13145

Q9D0L6

RefSeq (mRNA)

NM_012342

NM_026505

RefSeq (protein)

NP_036474

NP_080781

Location (UCSC)Chr 10: 28.68 – 28.68 MbChr 18: 3.51 – 3.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000095739 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024232 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)".
  6. Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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