GDF7

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.[5]

GDF7
Identifiers
AliasesGDF7, BMP12, growth differentiation factor 7
External IDsOMIM: 604651 MGI: 95690 HomoloGene: 32177 GeneCards: GDF7
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p24.1Start20,667,144 bp[1]
End20,679,243 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

151449

238057

Ensembl

ENSG00000143869

ENSMUSG00000037660

UniProt

Q7Z4P5

P43029

RefSeq (mRNA)

NM_182828

NM_013527
NM_001312876

RefSeq (protein)

NP_878248

NP_001299805
NP_038555

Location (UCSC)Chr 2: 20.67 – 20.68 MbChr 12: 8.3 – 8.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.[5][6]

GDF7 is also known as bone morphogenic protein 12 (BMP-12).[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000143869 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037660 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
  6. Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA. 102 (20): 7192–7. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.
  7. Peng C, Lei C, Guofei C, Tian Y, Wei L, Jianwei Z, Chen W, Wentao Z, Changqing J (2019). "The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair". International Journal of Biological Macromolecules. 138: 79–88. doi:10.1016/j.ijbiomac.2019.07.041. PMID 31295489.

Further reading


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