Indian hedgehog (protein)

Indian hedgehog homolog (Drosophila), also known as IHH, is a protein which in humans is encoded by the IHH gene.[5][6][7] This cell signaling protein is in the hedgehog signaling pathway. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the Indian hedgehog is honored by this one. The gene is not specific to Indian hedgehogs.

IHH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIHH, BDA1, HHG2, indian hedgehog, Indian hedgehog signaling molecule
External IDsOMIM: 600726 MGI: 96533 HomoloGene: 22586 GeneCards: IHH
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q35Start219,054,424 bp[1]
End219,060,921 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3549

16147

Ensembl

ENSG00000163501

ENSMUSG00000006538

UniProt

Q14623

P97812

RefSeq (mRNA)

NM_002181

NM_010544
NM_001313683

RefSeq (protein)

NP_002172

NP_001300612
NP_034674

Location (UCSC)Chr 2: 219.05 – 219.06 MbChr 1: 74.95 – 74.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Indian hedgehog protein is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) and sonic hedgehog (SHH).[8] It is involved in chondrocyte differentiation, proliferation and maturation especially during endochondral ossification. It regulates its effects by feedback control of parathyroid hormone-related peptide (PTHrP).[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000163501 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006538 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IHH Indian hedgehog homolog (Drosophila)".
  6. Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, Epstein DJ, Gilbert DJ, Copeland NG, Seidman CE (July 1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics. 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746.
  7. van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP (March 2004). "Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation". Nat. Genet. 36 (3): 277–82. doi:10.1038/ng1304. PMID 14770182.
  8. Kumar S, Balczarek KA, Lai ZC (March 1996). "Evolution of the hedgehog gene family". Genetics. 142 (3): 965–72. PMC 1207033. PMID 8849902.
  9. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (August 1996). "Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein". Science. 273 (5275): 613–22. Bibcode:1996Sci...273..613V. doi:10.1126/science.273.5275.613. PMID 8662546. S2CID 27737023.

Further reading

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