Isomorph (gene)
After Muller's classification was described as an isomorph, or gene mutation that expresses a nonsense point mutant with expression identical to the original allele.
Therefore, in respect of the relationships between the original and mutated genes it is difficult to ascertain the effects of dominanceness or/and recessiveness.[1][2] [3]
- Muller’s classification of mutant alleles
| Category | Alternative function |
| Wild type | Referent gene expression, normal expression of parent allele |
| Amorph | Dysfunctional, with null expression |
| Hypomorph | Reduced or partially reduced gene activity |
| Hypermorph | Increased or partially increased parent gene activity |
| Neomorph | Novel function, compared to the new property |
| Antimorph | Interfering with gene activity |
| Isomorph | Expression identical to the original (parent) allele, mostly resulting from silent point mutations |
See also
References
- Lawrence E., ed. (1999). Henderson's Dictionary of biological terms. London: Longman Group Ltd. ISBN 0-582-22708-9.
- Rieger R. Michaelis A., Green M. M. (1976). Glossary of genetics and cytogenetics: Classical and molecular. Berlin - Heidelberg - New York: Springer-Verlag. ISBN 3-540-07668-9.CS1 maint: uses authors parameter (link)
- http://www.its.caltech.edu/~bi190/SG4.pdf
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