Isosafrole

Isosafrole[1]
	; trans-Isosafrole
	; cis-Isosafrole
Names
	IUPAC name 5-(Prop-1-enyl)benzo[d][1,3]dioxole
	Other names 5-(1-Propenyl)-1,3-benzodioxole; 3,4-Methylenedioxyphenyl-1-propene
Identifiers
CAS Number	120-58-1 ; (trans): 4043-71-4 ; (cis): 17627-76-8 ;
3D model (JSmol)	Interactive image; (trans): Interactive image; (cis): Interactive image;
ChEBI	CHEBI:6054;
ChEMBL	ChEMBL487603 ;
ChemSpider	(trans): 21106329 ; (cis): 1266029;
ECHA InfoCard	100.004.010
EC Number	204-410-2; (cis): 241-611-4;
KEGG	C10472;
PubChem CID	(trans): 637796; (cis): 1549044;
RTECS number	(trans): DA5950000;
UNII	W6337429LF ; (trans): 94BY31ALL6 ; (cis): 253QUA24R1 ;
UN number	3082
CompTox Dashboard (EPA)	DTXSID2020767 ;
	InChI InChI=1S/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2-6H,7H2,1H3/b3-2+ Key: VHVOLFRBFDOUSH-NSCUHMNNSA-N ; InChI=1/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2-6H,7H2,1H3/b3-2+ Key: VHVOLFRBFDOUSH-NSCUHMNNBU;
	SMILES CC=Cc1ccc2OCOc2c1; (trans): C/C=C/C1=CC2=C(C=C1)OCO2; (cis): C/C=C\C1=CC2=C(C=C1)OCO2;
Properties
Chemical formula	C10H10O2
Molar mass	162.188 g·mol−1
Density	1.1206 g/cm3, trans; 1.1182 g/cm3, cis
Melting point	8.2 °C (46.8 °F; 281.3 K) trans; -21.5 °C, cis
Boiling point	255 °C (491 °F; 528 K) trans; 243 °C, cis
Hazards
GHS pictograms
GHS Signal word	Danger
GHS hazard statements	H302, H315, H341, H350
GHS precautionary statements	P201, P202, P264, P270, P280, P281, P301+312, P302+352, P308+313, P321, P330, P332+313, P362, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Isosafrole is an organic compound that is used in the fragrance industry. Structurally, the molecule is related to phenylpropene, a type of aromatic organic chemical. Its fragrance is reminiscent of anise or licorice. It is found in small amounts in various essential oils, but is most commonly obtained by isomerizing the plant oil safrole. It exists as two geometric isomers, cis-isosafrole and trans-isosafrole.

Isosafrole is a precursor to the important fragrance piperonal.[2] It can also be converted via the intermediate compound MDP2P into the psychoactive drug MDMA ('ecstasy'). As such it requires permits to purchase or sell in any significant quantity in the US.

References

Merck Index, 11th Edition, 5112
Karl-Georg Fahlbusch, Franz-Josef Hammerschmidt, Johannes Panten, Wilhelm Pickenhagen, Dietmar Schatkowski, Kurt Bauer, Dorothea Garbe and Horst Surburg "Flavors and Fragrances" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2003. doi:10.1002/14356007.a11_141

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[1] Merck Index, 11th Edition, 5112

[Ullmann-2] Karl-Georg Fahlbusch, Franz-Josef Hammerschmidt, Johannes Panten, Wilhelm Pickenhagen, Dietmar Schatkowski, Kurt Bauer, Dorothea Garbe and Horst Surburg "Flavors and Fragrances" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2003. doi:10.1002/14356007.a11_141