Kaley Cuoco

Cuoco made her first feature film appearance as the young Karin Carter in the 1995 action thriller Virtuosity.[9] From 2000 to 2001, she appeared on the CBS sitcom Ladies Man and in 2000 she portrayed former The Brady Bunch star Maureen McCormick in the TV film Growing Up Brady as well as starring in the Disney Channel original film Alley Cats Strike. In September 2002, she began a starring role as Bridget Hennessy on the ABC sitcom 8 Simple Rules for Dating My Teenage Daughter (afterwards 8 Simple Rules). Bridget was the oldest child, despite Cuoco being six years younger than Amy Davidson, who played her younger sister.

In addition to the final season of 8 Simple Rules, Cuoco had starring roles on the NBC miniseries 10.5, the ABC Family original film Crimes of Fashion, the independent film Debating Robert Lee,[10] and in the film The Hollow at the same time. She also voiced the character of Brandy Harrington, a 14-year-old anthropomorphic mixed-breed dog, on the Disney Channel animated series Brandy and Mr. Whiskers. She voiced the character of Kirstee Smith in Bratz from 2004 to 2005. In the eighth season of the TV series Charmed, she appeared as Billie Jenkins, a powerful young witch with the powers of telekinesis and projection. Executive producer Brad Kern stated that Cuoco's character was initially brought in as a possible spin-off.

Cuoco at the San Diego Comic-Con in July 2009

In September 2007, Cuoco began starring in the CBS sitcom The Big Bang Theory, playing Penny, a Cheesecake Factory employee and aspiring actress who lives across the hall from physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper. Prior to the 2010–2011 season, she earned US$60,000 an episode for the series, the same as her co-stars. In 2010, the cast negotiated a raise for each actor to make US$200,000 per episode.[11] As of August 2014, Cuoco and her co-stars from The Big Bang Theory Johnny Galecki and Jim Parsons each earned an estimated US$1 million per episode.[12]

In late October 2012, Cuoco enlisted the help of her sister Briana to organize a flash mob on the set of the show, in which she and the cast and crew surprised the studio audience by suddenly lip syncing and dancing to Carly Rae Jepsen's song "Call Me Maybe". A video of the event was posted on YouTube and became a viral success.[13][14] A clip from the performance was also played during Cuoco's January 8, 2013 appearance on the late-night talk show Conan.[15]

Cuoco at PaleyFest in March 2013

Cuoco starred in the Lifetime film To Be Fat like Me, which premiered on January 8, 2007.[16] She played a minor role in the Prison Break episodes "The Message" and "Chicago", as well as starring in the comedy horror spoof Killer Movie in 2008. She also appeared in the 2010 film The Penthouse. In 2011, she appeared in Allure magazine's annual "Naked Truth" feature.[17] That same year, she appeared in the films Hop and The Last Ride.[18] She was also chosen to host the Teen Choice Awards in 2011,[19] as well as the People's Choice Awards in 2012 and 2013.[20][21] She is a regular on Priceline.com commercials as the daughter of William Shatner's character.[22]

In October 2017, Cuoco founded Yes, Norman Productions, a television production company which entered an exclusive multi-year first-look production deal with Warner Bros. Television. Also in October 2017, the company optioned the rights to The Flight Attendant, a book written by author Chris Bohjalian, which was developed into a series of the same name with Cuoco starring as Cassandra "Cassie" Bowden, and also serving as executive producer.[23] In July 2019, The Flight Attendant had been picked up by WarnerMedia's streaming platform, HBO Max.[24][25] The series premiered on November 26, 2020 to widespread critical acclaim, and was renewed for a second season on December 18, 2020.[26][2][27]

In October 2018, it was announced that Cuoco would voice the title character of the DC Universe adult animation series Harley Quinn, and also serve as executive producer.[28] The series premiered on November 29, 2019 to critical acclaim.[29] In September 2020, it was announced that the series was renewed for a third season and would move to HBO Max.[30]

In August 2019, it was announced that Cuoco would executive produce the upcoming CBS comedy, Pretty, which is written and also executive produced by Lindsey Kraft and Santina Muha.[31] In April 2020, Cuoco joined the cast of the upcoming action comedy film The Man from Toronto as the female lead alongside Kevin Hart and Woody Harrelson.[32]