List of Major League Baseball career home run leaders

This is a list of the top 300 Major League Baseball leaders in home runs hit. In the sport of baseball, a home run is a hit in which the batter scores by circling all the bases and reaching home plate in one play, without the benefit of a fielding error. This can be accomplished either by hitting the ball out of play while it is still in fair territory (a conventional home run), or by an inside-the-park home run.

Barry Bonds holds the record for most career home runs, hitting 762 over his 22-year career.

Barry Bonds holds the Major League Baseball home run record with 762. He passed Hank Aaron, who hit 755, on August 7, 2007. The only other player to have hit 700 or more is Babe Ruth with 714. Alex Rodriguez (696), Albert Pujols (662), Willie Mays (660), Ken Griffey, Jr. (630), Jim Thome (612), and Sammy Sosa (609) are the only other players to have hit 600 or more.

Listed are all Major League Baseball players with 221 or more home runs hit during official regular season games (i.e., excluding playoffs or exhibition games). Players in bold face are active as of the 2020 Major League Baseball season (including free agents), with the number in parenthesis designating the number of home runs they have hit during the 2020 season. The last change in the cutoff for the top 300 occurred on September 4, 2020, when Josh Donaldson hit his 221st career home run, displacing Tony Oliva.