Mustard Database

Mustard is a database that tracks Antimicrobial Resistance Determinants (ARDs). The method by which it tracks ARDs is using their own method adapted from Protein Homology Modelling called Pairwise Comparative Modelling (PCM), which increase specificity protein prediction, especially for distantly related protein homologues.[1] Using PCM, 6095 ARDs from 20 families in the human gut microbiota. Antibiotic resistance databases used were ResFinder,[2] ARG-ANNOT,[3] the now defunct Lahey Clinic,[4] Marilyn Roberts website for tetracycline and macrolide resistance genes[5] and metagenomics.[6][7][8]

Mustard
Content
DescriptionContains AR determinants and curated AR genes identified from metagenomics
Data types
captured		Antimicrobial resistance genes and AR Determinants
OrganismsBacteria
Contact
Primary citationPMID 30478291
Access
Websitemgps.eu/Mustard/
Download URLDownload
Miscellaneous
Bookmarkable
entities		yes

See also

References
  1. Ehrlich, S. Dusko; Kennedy, Sean P.; Doré, Joël; Haimet, Florence; Weiszer, Kevin; Levenez, Florence; Letur, Aline; Léjard, Véronique; Léonard, Pierre (January 2019). "Prediction of the intestinal resistome by a three-dimensional structure-based method" (PDF). Nature Microbiology. 4 (1): 112–123. doi:10.1038/s41564-018-0292-6. ISSN 2058-5276. PMID 30478291. S2CID 53757858.
  2. Zankari, E.; Hasman, H.; Cosentino, S.; Vestergaard, M.; Rasmussen, S.; Lund, O.; Aarestrup, F. M.; Larsen, M. V. (2012-07-10). "Identification of acquired antimicrobial resistance genes". Journal of Antimicrobial Chemotherapy. 67 (11): 2640–2644. doi:10.1093/jac/dks261. ISSN 0305-7453. PMC 3468078. PMID 22782487.
  3. Gupta, Sushim Kumar; Padmanabhan, Babu Roshan; Diene, Seydina M.; Lopez-Rojas, Rafael; Kempf, Marie; Landraud, Luce; Rolain, Jean-Marc (2013-10-21). "ARG-ANNOT, a New Bioinformatic Tool To Discover Antibiotic Resistance Genes in Bacterial Genomes". Antimicrobial Agents and Chemotherapy. 58 (1): 212–220. doi:10.1128/aac.01310-13. ISSN 0066-4804. PMC 3910750. PMID 24145532.
  4. "RED-DB". Retrieved July 27, 2019.
  5. "Marilyn Roberts website".
  6. Allen, Heather K; Moe, Luke A; Rodbumrer, Jitsupang; Gaarder, Andra; Handelsman, Jo (2008-10-09). "Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil". The ISME Journal. 3 (2): 243–251. doi:10.1038/ismej.2008.86. ISSN 1751-7362. PMID 18843302. S2CID 16496336.
  7. Moore, Aimée M.; Patel, Sanket; Forsberg, Kevin J.; Wang, Bin; Bentley, Gayle; Razia, Yasmin; Qin, Xuan; Tarr, Phillip I.; Dantas, Gautam (2013-11-13). "Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance Genes". PLOS ONE. 8 (11): e78822. doi:10.1371/journal.pone.0078822. ISSN 1932-6203. PMID 24236055.
  8. Sommer, M. O. A.; Dantas, G.; Church, G. M. (2009-08-27). "Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora". Science. 325 (5944): 1128–1131. doi:10.1126/science.1176950. ISSN 0036-8075. PMC 4720503. PMID 19713526.


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