Phospholipid:diacylglycerol acyltransferase
In enzymology, a phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) is an enzyme that catalyzes the chemical reaction
- phospholipid + 1,2-diacylglycerol lysophospholipid + triacylglycerol
| phospholipid:diacylglycerol acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.158 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Beta-secretasePhospholipid:diacylglycerol acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BACE | ||||||||
| Pfam | PF02450 | ||||||||
| OPM superfamily | 127 | ||||||||
| OPM protein | 4x96 | ||||||||
| Membranome | 271 | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are phospholipid and 1,2-diacylglycerol, whereas its two products are lysophospholipid and triacylglycerol.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase. This enzyme is also called PDAT. This enzyme participates in glycerolipid metabolism.
An important human protein from this family is lecithin–cholesterol acyltransferase.
References
- Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S (June 2000). "Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants". Proceedings of the National Academy of Sciences of the United States of America. 97 (12): 6487–92. Bibcode:2000PNAS...97.6487D. doi:10.1073/pnas.120067297. PMC 18631. PMID 10829075.
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