Phospholipid:diacylglycerol acyltransferase

In enzymology, a phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) is an enzyme that catalyzes the chemical reaction

phospholipid + 1,2-diacylglycerol lysophospholipid + triacylglycerol
phospholipid:diacylglycerol acyltransferase
Identifiers
EC number2.3.1.158
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Beta-secretasePhospholipid:diacylglycerol acyltransferase
Identifiers
SymbolBACE
PfamPF02450
OPM superfamily127
OPM protein4x96
Membranome271

Thus, the two substrates of this enzyme are phospholipid and 1,2-diacylglycerol, whereas its two products are lysophospholipid and triacylglycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase. This enzyme is also called PDAT. This enzyme participates in glycerolipid metabolism.

An important human protein from this family is lecithin–cholesterol acyltransferase.

References

    • Dahlqvist A, Stahl U, Lenman M, Banas A, Lee M, Sandager L, Ronne H, Stymne S (June 2000). "Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants". Proceedings of the National Academy of Sciences of the United States of America. 97 (12): 6487–92. Bibcode:2000PNAS...97.6487D. doi:10.1073/pnas.120067297. PMC 18631. PMID 10829075.


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