KLF5

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[4][5]

KLF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDsOMIM: 602903 MGI: 1338056 HomoloGene: 37520 GeneCards: KLF5
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q22.1Start73,054,976 bp[1]
End73,077,541 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

688

12224

Ensembl

ENSG00000102554

ENSMUSG00000005148

UniProt

Q13887

Q9Z0Z7

RefSeq (mRNA)

NM_001730
NM_001286818

NM_009769

RefSeq (protein)

NP_001273747
NP_001721

NP_033899

Location (UCSC)Chr 13: 73.05 – 73.08 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[5]

Interactions

KLF5 has been shown to interact with Protein SET.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000102554 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research. 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902.
  5. "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
  6. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC 262669. PMID 14612398.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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