Pyr-T
Pyr-T (N,N-tetramethylenetryptamine) is a lesser-known, possible psychedelic drug. Pyr-T was first characterized by S. Mitzal.[1] Toxicity testing was later performed by Hunt and Brimblecombe, and although a lethal dosage was found in rats, a value is not given.[2] In the book TiHKAL (Tryptamines I Have Known and Loved), neither the dosage nor the duration are reported.[3]
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| Names | |
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| IUPAC name
3-(2-Pyrrolidin-1-ylethyl)-1H-indole | |
| Other names
N,N-Tetramethylenetryptamine | |
| Identifiers | |
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| Properties | |
| C14H18N2 | |
| Molar mass | 214.312 g·mol−1 |
| Melting point | 193 to 194 °C (379 to 381 °F; 466 to 467 K) (HCl salt.) |
| Boiling point | 170 to 180 °C (338 to 356 °F; 443 to 453 K) (Freebase at 0.05mm/Hg.) |
| log P | 2.74410 |
| Vapor pressure | 1.02x10−5mmHg |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Pyr-T produces few to no effects in humans, but some behavioral changes were observed in animal tests.[2] Very little data exists about the pharmacological properties, metabolism, and toxicity of pyr-T.
References
- Mitzal, S. (1962). "N/A". Dissertationes Pharm. 14: 305.
- Hunt, R. R.; Brimblecombe, R. W. (July 1967). "Synthesis and Biological Activity of Some Ring-Substituted Tryptamines". Journal of Medicinal Chemistry. 10 (4): 646–648. doi:10.1021/jm00316a027.
- Shulgin, Alexander; Shulgin, Ann (1997). TiHKAL, The Continuation (1st ed.). Berkeley, CA, USA: Transform Press. pp. 577–578. ISBN 0-9630096-9-9. Retrieved 7 April 2018.
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