Seveso disaster

The Seveso disaster was named because Seveso, with a population of 17,000 in 1976, was the community most affected. Other affected neighbouring communities were Meda (19,000), Desio (33,000), Cesano Maderno (34,000) and to a lesser extent Barlassina (6,000) and Bovisio-Masciago (11,000).[3] The industrial plant, located in Meda, was owned by the company ICMESA (Industrie Chimiche Meda Società Azionaria), a subsidiary of Givaudan, which in turn was a subsidiary of Hoffmann-La Roche (Roche Group). The factory building had been built many years earlier and the local population did not perceive it as a potential source of danger. Moreover, although several exposures of populations to dioxins had occurred before, mostly in industrial accidents, they were of a more limited scale.

The accident occurred in the chemical plant's building B. The chemical 2,4,5-trichlorophenol (2) was being produced there from 1,2,4,5-tetrachlorobenzene (1) by the nucleophilic aromatic substitution reaction with sodium hydroxide. The 2,4,5-trichlorophenol was intended as an intermediate for hexachlorophene.[4]

This reaction must be carried out at a temperature above what was achievable using the normal process utilities available at the plant, so it was decided to use the exhaust steam from the onsite electricity generation turbine, and pass that around an external heating coil installed on the chemical reactor vessel. The exhaust steam pressure was normally 12 bar and temperature 190 °C, which resulted in a reaction mixture temperature of 158 °C, very close to its boiling point of 160 °C. Safety testing showed the onset of an exothermic side reaction if the reaction mixture temperature reached 230 °C. Crucially, no steam temperature reading was made available to plant operators responsible for the reactor.

The chemical-release accident occurred when a batch process was interrupted prior to the completion of the final step – removal of ethylene glycol from the reaction mixture by distillation, due to conformance with an Italian law requiring shutdown of plant operations over the weekend. Other parts of the site had already started to close down as the processing of other batches finished, which reduced power consumption across the plant, causing a dramatic drop in the load on the turbine and a consequent increase in the temperature of the exhaust steam to around 300 °C. This much hotter steam then proceeded to heat the portion of the metal wall of the accident reactor above the level of the liquid within it to the same temperature. Not having a steam temperature reading among their instruments, operators of the reactor were unaware of the presence of this additional heating, and they stopped the batch as they normally would – by isolating the steam and turning off the stirrer in the reactor vessel. The abnormally-hot upper region of the reactor jacket then heated the adjacent reaction mixture. With the stirrer not running, the heating was highly localised – confined to just the portion of the upper layers of reaction mixture adjacent to the reactor wall, and increased the local temperature to the critical temperature for the exothermic side reaction seen in testing. Indeed, the critical temperature proved to be only 180 °C, 50 °C lower than believed. At that lower critical temperature, a slow runaway decomposition began, releasing more heat and leading to the onset of a rapid runaway reaction when the temperature reached 230 °C seven hours later.[5][6]

The reactor relief valve eventually opened, causing the aerial release of 6 tonnes of chemicals, which settled over 18 km² (6.9 sq mi) of the surrounding area.[7] Among the substances released was 1 kg of TCDD (3). At the nominal reaction temperature, TCDD is normally seen only in trace amounts of less than 1 ppm (parts per million).[8] However, in the higher-temperature conditions associated with the runaway reaction, TCDD production apparently reached 166 ppm or more.[9]

The affected area was split into zones A, B and R in decreasing order of surface soil concentrations of TCDD. Zone A was further split into 7 sub-zones. The local population was advised not to touch or eat locally grown fruits or vegetables.

• Zone A had a TCDD soil concentration of > 50 micrograms per square metre (μg/m²), it had 736 residents.
• Zone B had a TCDD soil concentration of between 5 and 50 μg/m², it had about 4700 residents.
• Zone R had negligible or a TCDD soil concentration of < 5 μg/m², it had 31,800 residents.

Within days a total of 3,300 animals, mostly poultry and rabbits, were found dead. Emergency slaughtering commenced to prevent TCDD from entering the food chain, and by 1978 over 80,000 animals had been slaughtered. 15 children were quickly hospitalised with skin inflammation. By the end of August, Zone A had been completely evacuated and fenced, 1,600 people of all ages had been examined and 447 were found to suffer from skin lesions or chloracne. An advice center was set up for pregnant women of whom only 26 opted for an abortion, which was legal in special cases, after consultation. Another 460 women continued their pregnancies without problems, their children not showing any sign of malformation. Herwig von Zwehl (Technical Director of ICMESA) and Paolo Paoletti (director of production at ICMESA) were arrested. Two government commissions were established to develop a plan for quarantining and decontaminating the area, for which the Italian government allotted 40 billion lire (US$47.8 million). This amount would be tripled two years later.

A 1991 study,[10] fourteen years after the accident, sought to assess the effects to the thousands of persons that had been exposed to dioxin. The most evident adverse health effect ascertained was chloracne (193 cases). Other early effects noted were peripheral neuropathy and liver enzyme induction. The ascertainment of other, possibly severe sequelae of dioxin exposure (e.g., birth defects) was hampered by inadequate information; however, generally, no increased risks were evident.

A study published in 1998 concluded that chloracne (nearly 200 cases with a definite exposure dependence) was the only effect established with certainty. Early health investigations including liver function, immune function, neurologic impairment, and reproductive effects yielded inconclusive results.

An excess mortality rate from cardiovascular and respiratory diseases was uncovered, and excess of diabetes cases was also found. Results of cancer incidence and mortality follow-up showed an increased occurrence of cancer of the gastrointestinal sites and of the lymphatic and hematopoietic tissue. Results cannot be viewed as final or comprehensive, however, because of various limitations: the lack of individual exposure data, short latency period, and small population size for certain cancer types.

A 2001 study[11] confirmed in victims of the disaster, that dioxin is carcinogenic to humans and corroborate its association with cardiovascular- and endocrine-related effects. In 2009, an update including 5 more years (up to 1996) found an increase in "lymphatic and hematopoietic tissue neoplasms" and increased breast cancer.[12]

A 2008 study[13] evaluated whether maternal exposure is associated with modified neonatal thyroid function in the highly exposed population in Seveso and concluded that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure.

The male children of mothers who were, during pregnancy of those children, exposed to high levels of toxic dioxins due to the Seveso disaster, have been found to have lower-than-average sperm counts. This result of the underlying Seveso study has been noted to provide the most pronounced evidence for prenatal exposure to an environmental chemical causing low sperm counts.[14]

In January 1977, an action plan consisting of scientific analysis, economic aid, medical monitoring and restoration/decontamination was completed. Shortly after ICMESA began to pay the first compensations to those affected. Later that spring decontamination operations were initiated and in June a system epidemiological health monitoring for 220,000 people was launched. They then used trichlorophenol to make a drug to fight the skin infections, which they tested in dogs.

In June 1978, the Italian government raised its special loan from 40 to 115 billion lire. By the end of the year, most individual compensation claims had been settled out of court. On February 5, 1980, Paolo Paoletti – the Director of Production at ICMESA – was shot and killed in Monza by a member of the Italian radical left-wing terrorist organization Prima Linea.[15]

On 19 December 1980, representatives of the Region of Lombardy/Italian Republic and Givaudan/ICMESA signed a compensation agreement in the presence of the prime minister of Italy, Arnaldo Forlani. The total amount would reach 20 billion lire.

After the incident, ICMESA initially refused to admit that the dioxin release had occurred. At least a week passed before a public statement was issued that dioxin had been emitted, and another week passed before an evacuation began. Even then, the government was saddled with the responsibility of determining the boundaries of the evacuation area, and thereafter to organise the evacuation. This constituted a major imposition on the community as well as on government resources.

It was soon recognized that the factory's very rudimentary safety systems had been designed with little more than simple explosion prevention in mind. Environmental protection had not been considered. Nor had any consideration been given as to setting up any type of warning system or health-protection protocols for the local community. As a result, the local population was caught unaware when the accident happened, and thus was unprepared to cope with the danger of an invisible poison.

In the context of such heightened tensions, Seveso became a microcosm where all the existing conflicts within society (political, institutional, religious, industrial) were reflected. However, within a relatively short time, such conflicts abated and the recovery of the community proceeded. For, in Seveso, the responsible party was known from the outset and soon offered reparation. Moreover, the eventual disappearance of the offending factory itself and the physical exportation of the toxic substances and polluted soil enabled the community to feel cleansed. The resolution of the emotional after-effects of the trauma, so necessary for the recovery of a community, was facilitated by these favourable circumstances."[16]

Industrial safety regulations were passed in the European Community in 1982 called the Seveso Directive,[17] which imposed much stronger industrial regulations. The Seveso Directive was updated in 1996, 2008 and 2012 and is currently referred to as the Seveso III Directive (or COMAH Regulations in the United Kingdom).

Treatment of the soil in the affected areas is now considered complete, since the dioxin levels are now below background. The entire site has been turned into a public park known as Seveso Oak Forest Park. This area is permanently off-limits to development. There are two artificial hills in the park; today, underneath these hills are the toxic remnants (including destroyed houses, tons of contaminated soil, and animal remains), all protected in a concrete sarcophagus. Investigations into site conditions have confirmed that the sarcophagus life expectancy of 300 years is expected, appropriate, and required.

Several studies have been completed on the health of the population of surrounding communities. While it has been established that people from Seveso exposed to TCDD are more susceptible to certain rare cancers, when all types of cancers are grouped into one category, no statistically significant increase has yet been reported in any specific cancer category. This indicates that more research is needed to determine the true long-term health effects on the affected population.

Epidemiological monitoring programmes were established as follows (with termination dates): abortions (1982); malformations (1982); tumours (1997); deaths (1997). Health monitoring of workers at ICMESA and on decontamination projects, and chloracne sufferers (1985).

The Seveso disaster gives valuable comparative insight into the effects of Agent Orange on flora and fauna in Vietnam, not to mention the Vietnamese people, as TCDD was a significant contaminant in Agent Orange.[18]

The documentary Gambit[19][20] is about Jörg Sambeth, the technical director of ICMESA, who was sentenced to five years in the first trial, and had his sentence reduced to two years and was paroled on appeal.[21]

• Environmental inequality in Europe
• Inochi No Chikyuu: Dioxin No Natsu (a 2001 film about the incident)
• "Suffocation," the fifth track on the dystopian concept album, See You Later, by Vangelis, is inspired by the Seveso disaster and features an emergency announcement in Italian to take shelter and a dialog between a man and woman set during the unfolding of the disaster.[22]
• "Seveso Directive", one of three European Union Directives to improve the safety of sites containing large quantities of dangerous substances:
  • Directive 82/501/EC, also known as the "Seveso Directive"
  • Directive 96/82/EC, also known as the "Seveso II Directive"
  • Directive 2012/18/EU, also known as the "Seveso III Directive"

• Fuller, John G. (1979). Poison That Fell from the Sky. New York: Berkley Books. ISBN 0-425-04013-5.
• Robbe, Federico (2016). Seveso 1976. Oltre la diossina. Castel Bolognese: Itaca Books. ISBN 978-88-526-0486-7.

• Loss Prevention Bulletin The Seveso Disaster: An appraisal of its causes and circumstances, Marshallvagri, V.C., LPB Issue 104, April 1992, IChemE, UK.
• National Pollutant Inventory - Dioxin Fact Sheet
• Dioxin: Seveso disaster testament to effects of dioxin, article by Mick Corliss, May 6, 1999.
• Icmesa chemical company, Seveso, Italy. July 9, 1976 British Health & Safety Executive COMAH information page on the Seveso Disaster.
• Assessment of the Health Risks of Dioxins, a 1998 report by the World Health Organization.
• Roche - 1965 - 1978 pdf History timeline at the homepage of Hoffmann-LaRoche.