Small nucleolar RNA SNORD27
Small nucleolar RNA SNORD27 (also known as U27 in mammals and snR74 in fungi) is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U27 is encoded within the U22 snoRNA host gene (UHG) in mammals[1] and is thought to act as a 2'-O-ribose methylation guide for ribosomal RNA.[2] This family also contains several related snoRNAs from yeast and plants.
| Small nucleolar RNA SNORD27 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD27 | |
| Identifiers | |
| Symbol | SNORD27 |
| Alt. Symbols | U27 |
| Rfam | RF00086 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
References
- Tycowski KT, Shu MD, Steitz JA (February 1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature. 379 (6564): 464–6. doi:10.1038/379464a0. PMID 8559254. S2CID 4319950.
- Tycowski KT, Smith CM, Shu MD, Steitz JA (December 1996). "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14480–5. doi:10.1073/pnas.93.25.14480. PMC 26158. PMID 8962077.
External links
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