Small nucleolar RNA SNORD51

SNORD51 (also known as U51) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD51
Predicted secondary structure and sequence conservation of SNORD51
Identifiers
Symbol	SNORD51
Alt. Symbols	U51
Rfam	RF00280
Other data
RNA type	Gene; snRNA; snoRNA; C/D-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

U51 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting.[2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S residue A1511.[3] In the human genome it is located in the introns of the same gene as the H/ACA box snoRNA ACA41.[3]