Small nucleolar RNA Z17

snoRNA Z17 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA Z17
Predicted secondary structure and sequence conservation of snoZ17
Identifiers
Symbol	snoZ17
Rfam	RF00266
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0001263
PDB structures	PDBe

snoRNA Z17 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA Z17B is predicted to guide the 2'-O-ribose methylation of 18S rRNA at position U121.[2] Two forms of this snoRNA are found in the intron of the ribosomal protein L23a gene.