Spider-Man: The City that Never Sleeps

Tara Platt in 2013

Laura Bailey in 2016

Platt and Bailey voiced Yuri Watanabe and Mary Jane Watson, respectively.

Spider-Man: The City that Never Sleeps features a large ensemble cast of characters from the history of Spider-Man comics. Peter Parker (voiced by Yuri Lowenthal)[7] is a 23-year old former research assistant,[8][9] who gained superhuman abilities after being bitten by a genetically-modified spider. Employing a secret identity, Parker uses these abilities to protect the citizens of New York City as the superhero Spider-Man.[10][7] Taking place shortly after the main story of Spider-Man, The City that Never Sleeps follows Parker, who is coming to terms with the loss of his Aunt May to a bioweapon released by his former friend and mentor turned archenemy, the now imprisoned Otto Octavius.[11] Parker has also romantically reunited with his ex-girlfriend Mary Jane Watson (Laura Bailey), a reporter and now currently the associate editor for the Daily Bugle, who occasionally aids Spider-Man and is aware of his secret identity. Peter has also began mentoring Miles Morales (Nadji Jeter) in using his abilities after the latter was also bitten by a similar genetically modified spider like Peter and gained similar powers.

The City that Never Sleeps introduces the first appearances of Parker's former lover and master-thief Black Cat / Felicia Hardy (Erica Lindbeck, who has a voice-only role in the main game),[12] Felicia's father and retired thief Walter Hardy (Daniel Riordan),[13][14] and mob boss Hammerhead (Keith Silverstein),[15] who is taking advantage of the power vacuum left by the absence of villains to attempt to seize control of the city's criminal underworld from the other Maggia crime families.[2] It also features several returning characters from the base game, including NYPD Captain and Spider-Man ally Yuri Watanabe (Tara Platt),[7] Silver Sablinova (Nichole Elise), leader of the private military company Sable International,[9] and the social media-using villain Screwball (Stephanie Lemelin), who escaped from prison.[3]

A few months after the events of the main game, the Maggia crime families are looking to fill the void in the criminal underworld left by Wilson Fisk's capture and Martin Li's defeat. While trying to stop one of the families from stealing a painting on display at the Manhattan Museum of Contemporary Art, Spider-Man encounters Felicia, who smashes the painting and steals a USB drive hidden within the frame before escaping. Mary Jane later informs him that Hammerhead's family is in possession of the drive, implying Felicia is working for them. Spider-Man pursues Felicia as she steals more drives, ultimately catching her, at which point she reveals that Hammerhead is holding her son hostage. Believing himself to be the father, Spider-Man agrees to help rescue the boy.

Meanwhile, Mary Jane learns that the drives contain the Maggia families' collective fortune, and that Hammerhead has recently purchased a large impregnable vault that could be used to hold Felicia's son. Spider-Man and Felicia storm the warehouse where the vault is kept, but the latter betrays and locks Spider-Man inside, revealing that she lied about having a son to persuade him into helping her break into the vault, which contains the final drive: Hammerhead's. As Spider-Man escapes, he overhears Hammerhead ordering his goons to kill Felicia for her betrayal. He attempts to warn her, but arrives too late and watches as she is seemingly killed when explosives planted in her penthouse detonate. Later, Peter tells Mary Jane that Felicia's body wasn't found among the wreckage, implying she survived, and that he is relieved to not be a father, though Mary Jane reassures him that he would make a great one someday, at the right time and with the right person.

Shortly after a full-blown gang war between the Maggia families erupts, Spider-Man assists Yuri Watanabe and her police task force in a raid against Hammerhead, though it turns out to be a trap, leaving only Spider-Man and Yuri alive. The loss of her men under her watch leaves Yuri emotionally compromised, and Spider-Man asks her to take a leave of absence to grieve and recover, promising to apprehend Hammerhead on his own. Spider-Man learns that Hammerhead and his gang have been stealing Sable International's equipment and weapons to gain an advantage in the gang war. After abducting the other Maggia Dons, Hammerhead's forces attack police convoys across the city. While Spider-Man is dealing with them, Hammerhead attacks the police precinct which is holding Sable International's "Project Olympus", killing numerous police officers in the process. Frustrated by her men's deaths and Spider-Man's lack of progress, Yuri decides to go after Hammerhead personally.

Later, Hammerhead, powered by the Project Olympus armor, decides to execute the Maggia Dons on live television to achieve his goal of terrorizing New York City into submission. Spider-Man foils Hammerhead's plan and defeats him, but before the police can apprehend him, a vengeful Yuri arrives and almost shoots Hammerhead dead, missing and hitting him in the head only because of Spider-Man's interference. Later, while Hammerhead's body is being taken away, one of his henchmen infiltrates the ambulance and resuscitates him.

Following her dismissal from the police force, Yuri has become a ruthless vigilante, tracking down and executing numerous Maggia gangsters. Meanwhile, with Sable International's advanced equipment and weaponry, Hammerhead's gang rules over the city. Learning of this, an enraged Silver Sablinova returns to take revenge on Hammerhead for stealing her supplies, which she needs for a civil war in her home country of Symkaria. Worried that Sablinova's violent methods would result in more chaos, Spider-Man tries to convince her to work together. Hammerhead, who has now upgraded himself into an advanced cyborg exoskeleton, leads Spider-Man and Sablinova into a trap and overpowers them. Felicia, who has faked her death, arrives to save Spider-Man, though Sablinova is captured by Hammerhead. Apologizing for her actions, Felicia gives Spider-Man a USB containing information on Hammerhead's weaknesses before disappearing again.

Spider-Man rescues Sablinova and they learn that the carbon steel plate inside Hammerhead's head is sensitive to heat. Sablinova takes Spider-Man to her stealth carrier on the Hudson River and they prepare a trap for Hammerhead, outfitting Sablinova's VTOL fighter jet with a heated laser array just before Hammerhead attacks them. While Spider-Man holds Hammerhead in place, Sablinova blasts his metal plate, weakening him, and crashes her jet into him. With Hammerhead subdued, Sablinova reclaims her supplies and returns to Symkaria, telling Spider-Man he inspired her to be more heroic. Meanwhile, Mary Jane also leaves for Symkaria to write a story on the war there and raise awareness, and Peter begins to train Miles Morales on how to use his newly acquired spider-powers, preparing him to become the next Spider-Man.