Tyrothricin

Tyrothricin is an antibiotic mixture which was isolated from Bacillus brevis by Rene Dubos in the late 1930s. It was later shown by Dubos and Rollin Hotchkiss to be a mixture of two different antibiotics: gramicidin and tyrocidine. [1]

Tyrothricin
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.014.337
  (verify)

Both gramicidin and tyrocidine are short polypeptides which disrupt the cell membranes of some, primarily Gram-positive, bacteria. Tyrothricin and its component antibiotics are too toxic to be taken internally but are sometimes used as topical antibiotics.

Tyrothricin, and its component antibiotics, belongs to the pharmacologically related group of polypeptide antibiotic compounds including colistin, polymyxin B, and bacitracin. There is no cross-resistance to these three agents.

References

  1. Hotchkiss RD, Dubos RJ (December 1940). "Bactericidal fractions from an aerobic sporulating bacillus" (PDF). Journal of Biological Chemistry. 136 (3): 803–804.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.