ABCC3

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.[5][6][7]

ABCC3
Identifiers
AliasesABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2, ATP binding cassette subfamily C member 3
External IDsOMIM: 604323 MGI: 1923658 HomoloGene: 68364 GeneCards: ABCC3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.33Start50,634,777 bp[1]
End50,692,253 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8714

76408

Ensembl

ENSG00000108846

ENSMUSG00000020865

UniProt

O15438

B2RX12

RefSeq (mRNA)

NM_001144070
NM_003786
NM_020037
NM_020038

NM_029600
NM_001363187
NM_001363189

RefSeq (protein)

NP_001137542
NP_003777

NP_083876
NP_001350116
NP_001350118

Location (UCSC)Chr 17: 50.63 – 50.69 MbChr 11: 94.34 – 94.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to oxidative stress.[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000108846 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020865 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Dec 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J Natl Cancer Inst. 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529.
  7. "Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3".
  8. Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ (2014-10-27). "Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene". Drug Metabolism and Disposition. 43 (1): 93–99. doi:10.1124/dmd.114.060103. PMC 4279086. PMID 25349122.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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