ABCC11
ATP-binding cassette transporter sub-family C member 11, also MRP8 (Multidrug Resistance-Related Protein 8) is a membrane transporter that exports certain molecules from inside a cell. It is a protein that in humans is encoded by gene ABCC11.[3][4][5]
The gene is responsible for determination of human cerumen type (wet or dry ear wax) and presence of underarm osmidrosis (odor associated with sweat caused by excessive apocrine secretion).
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The ABCC11 transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a single nucleotide polymorphism (SNP) in this gene is responsible for determination of human earwax type and presence of underarm odour. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.[5]
Molecular genetics
The ABCC11 gene is present in the human genome as two alleles, differing in one nucleotide also known as a single nucleotide polymorphism (SNP).[6] A SNP in the ABCC11 gene on chromosome 16 at base position 538 of either a guanine or adenine determines two distinct groups of phenotypes.[6][7] These respectively code for glycine and arginine in the gene's protein product. Dominant inheritance of the GG or GA genotype is observed while the AA genotype is recessive. The phenotypes expressed by the genotypes include cerumen type (wet or dry ear wax), osmidrosis (odor associated with sweat caused by excessive apocrine secretion), and possibly breast cancer risk, although there is ongoing debate on whether there is a real correlation of the wet ear wax phenotype to breast cancer susceptibility.[8][9] The GG or GA genotype produces the wet ear wax phenotype (sticky and brown colored) and acrid sweat odor and is the dominant allele.[8] Note this phenotype requires only the presence of one guanine. The homozygous recessive AA genotype produces the dry ear wax phenotype (dry and flaky) and mildly odored sweat.[8]
The alleles containing a guanine produce a protein that is glycosylated but alleles containing an adenine are not glycosylated. The resulting protein is only partially degraded by proteasomes.[6] This effect is localized to ceruminous gland membranes.[6] Because the adenine containing allele protein product is only partially degraded, the remaining functional protein is located on the cell surface membrane which ABCC11 gene's role in sweat odor is likely in part due to the quantitative dosage of ABCC11 protein.[6]
From an evolutionary perspective, the implications of cerumen type on fitness are unknown. Although odorless sweat in ancient Northern Eurasian populations have been postulated to have an adaptive advantage for cold weather.[7] In some nonhuman mammals, mating signals via release of an odor enhanced by increased apocrine secretion may be a factor in sexual selection.[7]
Physical human traits that are controlled by a single gene are uncommon. Most human characteristics are controlled by multiple genes (polygenes); ABCC11 is a peculiar example of a gene with unambiguous phenotypes that is controlled by a SNP. Additionally, it is considered a pleiotropic gene.
Demographics
The history of the migration of humans can be traced back using the ABCC11 gene alleles. The variation between ear wax and body odor in ethnicities around the world are specifically due to the ABCC11 gene alleles.[7] It is hypothesized that 40,000 years ago, an ancient Mongoloid tribe evolved the dry ear wax phenotype that followed a spread of the dry ear wax allele to other regions of Asia via migration of the ancient tribe.[10] The gene spread as a result of it being a beneficial adaption or through an evolutionary neutral mutation mechanism that went through genetic drift events.[10]
The frequency of alleles for dry ear wax and odorless sweat is most concentrated in East- and Northeast Asia, most notably Korea, China, Mongolia, and western Japan.[7] A downward gradient of dry ear wax allele phenotypes can be drawn from northern China to southern Asia and an east–west gradient can also be drawn from eastern Siberia to western Europe.[7] The allele frequencies within ethnicities continued to be maintained because the ABCC11 gene is inherited as a haplotype, a group of genes or alleles that tend to be inherited as a single unit[7][11]
The amount of volatile organic compounds (VOCs) in ear wax was found to be related to variation in ABCC11 genotype, which in turn is dependent on ethnic origin. In particular, the rs17822931 genotype, which is especially prevalent in East Asians, is correlated with lower VOC levels. However, VOC levels were not found to vary significantly qualitatively nor quantitatively for most organic compounds by racial group after Bonferroni corrections, suggesting that it does not result in ethnic differences.[12]
See also
References
Citations
- GRCh38: Ensembl release 89: ENSG00000121270 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, Schuetz JD, Swoboda KJ, Ptácek LJ, Rosier M, Dean M, Allikmets R (Jul 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364.
- Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 (7): 1156–66. doi:10.1101/gr.184901 (inactive 2021-01-14). PMID 11435397.CS1 maint: DOI inactive as of January 2021 (link)
- "Entrez Gene: ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11".
- Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T (Jun 2009). "Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?". FASEB Journal. 23 (6): 2001–13. doi:10.1096/fj.09-129098. PMID 19383836. S2CID 26853548.
- Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, et al. (Mar 2006). "A SNP in the ABCC11 gene is the determinant of human earwax type". Nature Genetics. 38 (3): 324–30. doi:10.1038/ng1733. PMID 16444273. S2CID 3201966.
- Rodriguez S, Steer CD, Farrow A, Golding J, Day IN (Jul 2013). "Dependence of deodorant usage on ABCC11 genotype: scope for personalized genetics in personal hygiene". The Journal of Investigative Dermatology. 133 (7): 1760–7. doi:10.1038/jid.2012.480. PMC 3674910. PMID 23325016.
- Park YJ, Shin MS (Sep 2001). "What is the best method for treating osmidrosis?". Annals of Plastic Surgery. 47 (3): 303–9. doi:10.1097/00000637-200109000-00014. PMID 11562036. S2CID 25590802.
- Ishikawa T, Toyoda Y, Yoshiura K, Niikawa N (2012-01-01). "Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion". Frontiers in Genetics. 3: 306. doi:10.3389/fgene.2012.00306. PMC 3539816. PMID 23316210.
- Prokop-Prigge KA, Mansfield CJ, Parker MR, Thaler E, Grice EA, Wysocki CJ, Preti G (Jan 2015). "Ethnic/racial and genetic influences on cerumen odorant profiles". Journal of Chemical Ecology. 41 (1): 67–74. doi:10.1007/s10886-014-0533-y. PMC 4304888. PMID 25501636.
- Prokop-Prigge KA, Greene K, Varallo L, Wysocki CJ, Preti G (2016). "The Effect of Ethnicity on Human Axillary Odorant Production". Journal of Chemical Ecology. 42 (1): 33–9. doi:10.1007/s10886-015-0657-8. PMC 4724538. PMID 26634572.
Sources
- This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Further reading
- Bera TK, Lee S, Salvatore G, Lee B, Pastan I (Aug 2001). "MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer". Molecular Medicine. 7 (8): 509–16. doi:10.1007/BF03401856. PMC 1950066. PMID 11591886.
- Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (Nov 2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12". Biochemical and Biophysical Research Communications. 288 (4): 933–9. doi:10.1006/bbrc.2001.5865. PMID 11688999.
- Lai L, Tan TM (Feb 2002). "Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues". The Biochemical Journal. 361 (Pt 3): 497–503. doi:10.1042/0264-6021:3610497. PMC 1222332. PMID 11802779.
- Stríz I, Jaresová M, Lácha J, Sedlácek J, Vítko S (2002). "MRP 8/14 and procalcitonin serum levels in organ transplantations". Annals of Transplantation. 6 (2): 6–9. PMID 11803621.
- Tomita H, Yamada K, Ghadami M, Ogura T, Yanai Y, Nakatomi K, Sadamatsu M, Masui A, Kato N, Niikawa N (Jun 2002). "Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16". Lancet. 359 (9322): 2000–2. doi:10.1016/S0140-6736(02)08835-9. PMID 12076558. S2CID 20226277.
- Turriziani O, Schuetz JD, Focher F, Scagnolari C, Sampath J, Adachi M, Bambacioni F, Riva E, Antonelli G (Nov 2002). "Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11". The Biochemical Journal. 368 (Pt 1): 325–32. doi:10.1042/BJ20020494. PMC 1222956. PMID 12133003.
- Guo Y, Kotova E, Chen ZS, Lee K, Hopper-Borge E, Belinsky MG, Kruh GD (Aug 2003). "MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine". The Journal of Biological Chemistry. 278 (32): 29509–14. doi:10.1074/jbc.M304059200. PMID 12764137. S2CID 6081066.
- Bouma G, Lam-Tse WK, Wierenga-Wolf AF, Drexhage HA, Versnel MA (Aug 2004). "Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin". Diabetes. 53 (8): 1979–86. doi:10.2337/diabetes.53.8.1979. PMID 15277376.
- Vogl T, Ludwig S, Goebeler M, Strey A, Thorey IS, Reichelt R, Foell D, Gerke V, Manitz MP, Nacken W, Werner S, Sorg C, Roth J (Dec 2004). "MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes". Blood. 104 (13): 4260–8. doi:10.1182/blood-2004-02-0446. PMID 15331440.
- Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD (Feb 2005). "Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)". Molecular Pharmacology. 67 (2): 545–57. doi:10.1124/mol.104.007138. PMID 15537867. S2CID 18527978.
- Bortfeld M, Rius M, König J, Herold-Mende C, Nies AT, Keppler D (2006). "Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system". Neuroscience. 137 (4): 1247–57. doi:10.1016/j.neuroscience.2005.10.025. PMID 16359813. S2CID 22719472.
- Viemann D, Barczyk K, Vogl T, Fischer U, Sunderkötter C, Schulze-Osthoff K, Roth J (Mar 2007). "MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program". Blood. 109 (6): 2453–60. doi:10.1182/blood-2006-08-040444. PMID 17095618.
External links
Wikimedia Commons has media related to ABCC11. |
- ABCC11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human ABCC11 genome location and ABCC11 gene details page in the UCSC Genome Browser.